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    pks12 polyketide synthase [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888350, updated on 17-Apr-2021

    Summary

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    Gene symbol
    pks12
    Gene description
    polyketide synthase
    Locus tag
    Rv2048c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (2294531..2306986, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene lipoprotein LppI Neighboring gene ncRNA Neighboring gene hypothetical protein Neighboring gene RNA polymerase-binding protein RbpA Neighboring gene polyprenol-monophosphomannose synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells. Matsunaga I, et al. J Exp Med, 2004 Dec 20. PMID 15611286, Free PMC Article
    2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pks12 is necessary for production of polyketide, designated mycoketide.
      Title: Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    polyketide synthase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      2294531..2306986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_216564.2 polyketide synthase [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_216564.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      I6XD69
      Conserved Domains (5) summary
      cd08956
      Location:1679 → 1933
      KR_3_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x)
      smart00823
      Location:3985 → 4070
      PKS_PP; Phosphopantetheine attachment site
      smart00829
      Location:3419 → 3700
      PKS_ER; Enoylreductase
      COG3321
      Location:2054 → 3125
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
      cl21454
      Location:3226 → 3396
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    I6XD69.1

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