U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    lprG lipoprotein LprG [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 886700, updated on 6-Aug-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    lprG
    Gene description
    lipoprotein LprG
    Locus tag
    Rv1411c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Also known as
    P27
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000962.3 (1587772..1588482, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene ribulose-phosphate 3-epimerase Neighboring gene bifunctional riboflavin biosynthesis diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino) uracil reductase Neighboring gene aminoglycosides/tetracycline-transport integral membrane protein Neighboring gene riboflavin synthase Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Protein O-mannosylation deficiency increases LprG-associated lipoarabinomannan release by Mycobacterium tuberculosis and enhances the TLR2-associated inflammatory response. Alonso H, et al. Sci Rep, 2017 Aug 11. PMID 28801649, Free PMC Article
    2. A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A. Touchette MH, et al. ACS Infect Dis, 2017 May 12. PMID 28276676, Free PMC Article
    3. Mycobacterium tuberculosis lipoprotein LprG binds lipoarabinomannan and determines its cell envelope localization to control phagolysosomal fusion. Shukla S, et al. PLoS Pathog, 2014 Oct. PMID 25356793, Free PMC Article
    4. Aggravated infection in mice co-administered with Mycobacterium tuberculosis and the 27-kDa lipoprotein. Hovav AH, et al. Microbes Infect, 2006 Jun. PMID 16815070
    5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, the authors demonstrated that the Mycobacterium tuberculosis mutant (Deltapmt) deficient for protein O-mannosylation exhibits enhanced release of lipoarabinomannan (LAM) in a complex with LprG, a lipoprotein required for LAM translocation to the cell surface.
      Title: Protein O-mannosylation deficiency increases LprG-associated lipoarabinomannan release by Mycobacterium tuberculosis and enhances the TLR2-associated inflammatory response.
    2. A screen for protein-protein interactions reveals a functional link between the virulence-associated lipid transporter LprG and the mycolyltransferase antigen 85A.
      Title: A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A.
    3. LprG binding to lipoarabinomannan (LAM) facilitates its transfer from the plasma membrane into the cell envelope.
      Title: Mycobacterium tuberculosis lipoprotein LprG binds lipoarabinomannan and determines its cell envelope localization to control phagolysosomal fusion.
    4. data suggest that the 27-kDa lipoprotein plays a role in Mtb infection by inducing increased suppression of the immune response due to elevated nitric oxide production
      Title: Aggravated infection in mice co-administered with Mycobacterium tuberculosis and the 27-kDa lipoprotein.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    lipoprotein LprG
    NP_215927.1
    • A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004 PMID:14766927).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      1587772..1588482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_215927.1 lipoprotein LprG [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_215927.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0E9AD62
      Conserved Domains (1) summary
      pfam07161
      Location:40 → 230
      LppX_LprAFG; LppX_LprAFG lipoprotein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WK45.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Miscellaneous