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    def polypeptide deformylase [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 886366, updated on 6-Oct-2023

    Summary

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    Gene symbol
    def
    Gene description
    polypeptide deformylase
    Locus tag
    Rv0429c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (517803..518396, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene transmembrane protein Neighboring gene exodeoxyribonuclease III protein XthA Neighboring gene GCN5-like N-acetyltransferase Neighboring gene hypothetical protein Neighboring gene tuberculin-like peptide

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycine in the conserved motif III modulates the thermostability and oxidative stress resistance of peptide deformylase in Mycobacterium tuberculosis. Narayanan SS, et al. FEMS Microbiol Lett, 2011 Jul. PMID 21507054
    2. The carboxy-terminal end of the peptide deformylase from Mycobacterium tuberculosis is indispensable for its enzymatic activity. Saxena R, et al. Biochem Biophys Res Commun, 2005 Jul 1. PMID 15896710
    3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glycine in the conserved motif III modulates the thermostability and oxidative stress resistance of peptide deformylase.
      Title: Glycine in the conserved motif III modulates the thermostability and oxidative stress resistance of peptide deformylase in Mycobacterium tuberculosis.
    2. Our results, through deletion analysis, for the first time established the role of this region in mPDF enzyme activity.
      Title: The carboxy-terminal end of the peptide deformylase from Mycobacterium tuberculosis is indispensable for its enzymatic activity.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    polypeptide deformylase
    NP_214943.1
    • Cofactor: binds 1 zinc ion.

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      517803..518396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_214943.1 polypeptide deformylase [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_214943.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2I7W3I8
      Conserved Domains (1) summary
      PRK00150
      Location:1 → 178
      def; peptide deformylase; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WIJ3.1

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