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    ras raspberry [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43873, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rasprovided by FlyBase
    Official Full Name
    raspberryprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003204
    Locus tag
    Dmel_CG1799
    See related
    AllianceGenome:FB:FBgn0003204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11485; CG1799; Dmel\CG1799; EP(X)1093; IMPdH; IMPDH; l(1)9Eb; l(1)G0002; l(1)G0056; l(1)G0098; l(1)G0127; l(1)G0238; l(1)G0351; l(1)G0380; l(1)G0388; l(1)G0391; l(1)G0436; l(1)G0482; LD02673; LD06825; Ras; ras-l; raspberry/impd
    Summary
    Predicted to enable IMP dehydrogenase activity. Involved in axon guidance. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; cuboidal/columnar epithelium; embryonic/larval midgut primordium; gonad; and mesoderm. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to several human genes including IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ras in Genome Data Viewer
    Location:
    9E1-9E2; 1-32 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10744502..10749097)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10638535..10643130)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene X11Lbeta Neighboring gene Rab at 9E Neighboring gene uncharacterized protein Neighboring gene stuxnet Neighboring gene long non-coding RNA:CR44766 Neighboring gene Rabphilin Neighboring gene Transport and Golgi organization 5 Neighboring gene Autophagy-related 8a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Temperature-sensitive mutations in Drosophila melanogaster. V. A mutation affecting concentrations of pteridines. Grigliatti T, et al. Proc Natl Acad Sci U S A, 1970 Nov. PMID 5274440, Free PMC Article
    2. The raspberry locus of Drosophila melanogaster includes an inosine monophosphate dehydrogenase like coding sequence. Nash D, et al. Genome, 1994 Apr. PMID 7911114
    3. Cloning and sequence analysis of a Drosophila melanogaster cDNA encoding IMP dehydrogenase. Sifri CD, et al. Biochim Biophys Acta, 1994 Jan 18. PMID 7904480
    4. Genetic rescue of inviable hybrids between Drosophila melanogaster and its sibling species. Hutter P, et al. Nature, 1987 May 28-Jun 3. PMID 3108667
    5. A genetic basis for the inviability of hybrids between sibling species of Drosophila. Hutter P, et al. Genetics, 1990 Apr. PMID 2108905, Free PMC Article

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tissue-autonomous immune response regulates stress signaling during hypertrophy.
      Title: Tissue-autonomous immune response regulates stress signaling during hypertrophy.
    2. EGFR/ARF6 regulation of Hh signaling stimulates oncogenic Ras tumor overgrowth in Drosophila.
      Title: EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth.
    3. Ras-Dsor1 activity is independent of upstream activation by EGFR, and instead it appears to be activated by the insulin-like growth factor receptor to promote Wg signaling.
      Title: Ras-activated Dsor1 promotes Wnt signaling in Drosophila development.
    4. Drosophila inosine 5'-monophosphate dehydrogenase (IMPDH), encoded by raspberry (ras), is centrally important for a proper cellular immune response against eggs from the parasitoid wasp Leptopilina boulardi
      Title: The raspberry Gene Is Involved in the Regulation of the Cellular Immune Response in Drosophila melanogaster.
    5. Loss-of-function mutations in dPLZF resulted in a dramatic suppression of the extra and ectopic vein formation induced by elevated Ras/ERK signaling.
      Title: The BTB/POZ-ZF transcription factor dPLZF is involved in Ras/ERK signaling during Drosophila wing development.
    6. Data show that inosine monophosphate dehydrogenase (IMPDH) binds sequence specifically to single-stranded, CT-rich DNA elements.
      Title: Metabolic enzyme IMPDH is also a transcription factor regulated by cellular state.
    7. Ectopic Ras/MAPK pathway activation results in the suppression of Drosophila IMD/NF-kappaB signalling.
      Title: Drosophila Ras/MAPK signalling regulates innate immune responses in immune and intestinal stem cells.
    8. Constitutive coactivation of EGFR-Ras and PI3K pathways in glia and glial precursors gives rise to neoplastic, invasive glial cells.
      Title: A drosophila model for EGFR-Ras and PI3K-dependent human glioma.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables IMP dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables IMP dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables IMP dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in GTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    raspberry
    Names
    CG1799-PA
    CG1799-PC
    CG1799-PD
    CG1799-PE
    CG1799-PF
    IMP dehydrogenase
    inosine monophosphate dehydrogenase
    lethal (1) G0380
    ras-PA
    ras-PC
    ras-PD
    ras-PE
    ras-PF
    raspberry-lethal
    NP_001259427.1
    NP_001356940.1
    NP_524646.5
    NP_727441.1
    NP_727442.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10744502..10749097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272498.2 → NP_001259427.1  raspberry, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259427.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07152, Q26455, Q8SXM5, Q9W2R8
      UniProtKB/TrEMBL
      A4V488
      Conserved Domains (3) summary
      cd00381
      Location:51 → 505
      IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
      cd04602
      Location:137 → 249
      CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
      PTZ00314
      Location:38 → 533
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    2. NM_167240.3 → NP_727441.1  raspberry, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727441.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07152, Q26455, Q8SXM5, Q9W2R8
      UniProtKB/TrEMBL
      A4V488
      Related
      FBpp0071424
      Conserved Domains (3) summary
      cd00381
      Location:51 → 505
      IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
      cd04602
      Location:137 → 249
      CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
      PTZ00314
      Location:38 → 533
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    3. NM_001369990.1 → NP_001356940.1  raspberry, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K3W6
      Conserved Domains (1) summary
      PTZ00314
      Location:38 → 533
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    4. NM_079907.7 → NP_524646.5  raspberry, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524646.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07152, Q26455, Q8SXM5, Q9W2R8
      UniProtKB/TrEMBL
      A4V488
      Conserved Domains (3) summary
      cd00381
      Location:51 → 505
      IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
      cd04602
      Location:137 → 249
      CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
      PTZ00314
      Location:38 → 533
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    5. NM_167241.3 → NP_727442.1  raspberry, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727442.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07152, Q26455, Q8SXM5, Q9W2R8
      UniProtKB/TrEMBL
      A4V488
      Related
      FBpp0071423
      Conserved Domains (3) summary
      cd00381
      Location:51 → 505
      IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
      cd04602
      Location:137 → 249
      CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
      PTZ00314
      Location:38 → 533
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4D6K3W6 A0A4D6K3W6
    A4V488 A4V488
    Q07152.1 Q07152

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