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    Ndf Nucleosome-destabilizing factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 192507, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ndfprovided by FlyBase
    Official Full Name
    Nucleosome-destabilizing factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0043456
    Locus tag
    Dmel_CG4747
    See related
    AllianceGenome:FB:FBgn0043456
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH19401; BEST:LD22483; BEST:LD29743; CG4747; Dmel\CG4747; Dm_AI388468; dNDF; LD29743; NDF
    Summary
    Enables DNA binding activity and nucleosome binding activity. Involved in sex-chromosome dosage compensation and transcription elongation-coupled chromatin remodeling. Located in polytene chromosome interband. Is expressed in adult head; adult heart; and organism. Orthologous to human GLYR1 (glyoxylate reductase 1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ndf in Genome Data Viewer
    Location:
    30F5-30F5; 2-38 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10003832..10008889)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10003832..10008889)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR13130 Neighboring gene big brain Neighboring gene uncharacterized protein Neighboring gene Sister of Yb Neighboring gene antisense RNA:CR44873 Neighboring gene Translocation protein 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation? Stec I, et al. FEBS Lett, 2000 May 4. PMID 10802047
    2. NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes. Fei J, et al. Genes Dev, 2018 May 1. PMID 29759984, Free PMC Article
    3. Dynamics of nuclear matrix proteome during embryonic development in Drosophila melanogaster. Varma P, et al. J Biosci, 2011 Aug. PMID 21799256
    4. Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. Wang CI, et al. Nat Struct Mol Biol, 2013 Feb. PMID 23295261, Free PMC Article
    5. The gene search system. A method for efficient detection and rapid molecular identification of genes in Drosophila melanogaster. Toba G, et al. Genetics, 1999 Feb. PMID 9927464, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CG4747 and Set2 function together to facilitate targeting of the male-specific lethal complex to active genes.
      Title: Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sex-chromosome dosage compensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation-coupled chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation-coupled chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nucleosome-destabilizing factor
    Names
    CG4747-PA
    CG4747-PB
    CG4747-PC
    Ndf-PA
    Ndf-PB
    Ndf-PC
    nucleosome-destabilizing factor
    NP_001188767.1
    NP_001285791.1
    NP_609336.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10003832..10008889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201838.2 → NP_001188767.1  Nucleosome-destabilizing factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188767.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRG2
      Conserved Domains (4) summary
      cd05836
      Location:20 → 106
      N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
      COG2084
      Location:319 → 597
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
      pfam03446
      Location:316 → 477
      NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
      pfam14833
      Location:481 → 597
      NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

    2. NM_135492.5 → NP_609336.3  Nucleosome-destabilizing factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609336.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T079, Q9VL51
      UniProtKB/TrEMBL
      X2JDP6
      Related
      FBpp0079520
      Conserved Domains (3) summary
      cd05836
      Location:20 → 106
      N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
      COG2084
      Location:319 → 596
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
      PRK00708
      Location:176 → 267
      PRK00708; twin-arginine translocase subunit TatB

    3. NM_001298862.1 → NP_001285791.1  Nucleosome-destabilizing factor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285791.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T079, Q9VL51
      UniProtKB/TrEMBL
      X2JDP6
      Conserved Domains (3) summary
      cd05836
      Location:20 → 106
      N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
      COG2084
      Location:319 → 596
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
      PRK00708
      Location:176 → 267
      PRK00708; twin-arginine translocase subunit TatB
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MRG2 M9MRG2
    Q8T079.1 Q8T079
    X2JDP6 X2JDP6

    Gene LinkOut

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