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    ntc nutcracker [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38443, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ntcprovided by FlyBase
    Official Full Name
    nutcrackerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035461
    Locus tag
    Dmel_CG10855
    See related
    AllianceGenome:FB:FBgn0035461
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10855; Dmel\CG10855; FBXO7
    Summary
    Enables cysteine-type endopeptidase activator activity involved in apoptotic process. Involved in several processes, including positive regulation of mitophagy; protein stabilization; and sperm individualization. Part of SCF ubiquitin ligase complex. Is expressed in cystic bulge and organism. Used to study Parkinson's disease 15. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ntc in Genome Data Viewer
    Location:
    63F1-63F1; 3-9 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3803832..3806459, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3803832..3806459, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pickpocket 27 Neighboring gene uncharacterized protein Neighboring gene Integrator 10 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel. Frochaux MV, et al. Genome Biol, 2020 Jan 17. PMID 31948474, Free PMC Article
    2. Drosophila Skp1 Homologue SkpA Plays a Neuroprotective Role in Adult Brain. Dabool L, et al. iScience, 2020 Aug 21. PMID 32739834, Free PMC Article
    3. The FBXO7 homologue nutcracker and binding partner PI31 in Drosophila melanogaster models of Parkinson's disease. Merzetti EM, et al. Genome, 2017 Jan. PMID 27936908
    4. FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo. Sanchez-Martinez A, et al. PLoS Biol, 2023 Aug. PMID 37535686, Free PMC Article
    5. A conserved F box regulatory complex controls proteasome activity in Drosophila. Bader M, et al. Cell, 2011 Apr 29. PMID 21529711, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activator activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
    Inferred from Sequence Model
    more info
    		  
    involved_in positive regulation of mitophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    nutcracker
    Names
    CG10855-PA
    ntc-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3803832..3806459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139572.3 → NP_647829.1  nutcracker [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647829.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SX86, Q9VZM8
      Related
      FBpp0073041
      Conserved Domains (1) summary
      pfam00646
      Location:265 → 310
      F-box; F-box domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SX86.1 Q8SX86

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