U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Snx21 Sorting nexin 21 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33466, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Snx21provided by FlyBase
    Official Full Name
    Sorting nexin 21provided by FlyBase
    Primary source
    FLYBASE:FBgn0031457
    Locus tag
    Dmel_CG3077
    See related
    AllianceGenome:FB:FBgn0031457
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3077; Dmel\CG3077; DmSNX21; snx21
    Summary
    Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in protein transport. Predicted to be active in early endosome membrane. Is expressed in organism. Orthologous to human SNX20 (sorting nexin 20) and SNX21 (sorting nexin family member 21). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Snx21 in Genome Data Viewer
    Location:
    23A5-23A5; 2-7 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2763416..2765665, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2763416..2765665, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Bacchus Neighboring gene long non-coding RNA:CR44772 Neighboring gene SNAP associated protein Neighboring gene HemK methyltransferase 2 Neighboring gene Transportin-Serine/Arginine rich Neighboring gene anterior pharynx defective 1 Neighboring gene TBP-associated factor 10b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Snazarus and its human ortholog SNX25 modulate autophagic flux. Lauzier A, et al. J Cell Sci, 2022 Mar 1. PMID 34821359
    2. SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless. Zhang P, et al. Cell Res, 2011 Dec. PMID 22041890, Free PMC Article
    3. Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Eulalio A, et al. Genes Dev, 2007 Oct 15. PMID 17901217, Free PMC Article
    4. An SH3PX1-Dependent Endocytosis-Autophagy Network Restrains Intestinal Stem Cell Proliferation by Counteracting EGFR-ERK Signaling. Zhang P, et al. Dev Cell, 2019 May 20. PMID 31006650, Free PMC Article
    5. Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors. Tegeder I, et al. J Neurooncol, 2019 Jan. PMID 30446899

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    sorting nexin 21
    Names
    CG3077-PA
    CG3077-PB
    Snx21-PA
    Snx21-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2763416..2765665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273033.1 → NP_001259962.1  sorting nexin 21, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259962.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBU4
      Conserved Domains (1) summary
      cd07279
      Location:65 → 182
      PX_SNX20_21_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 20 and 21

    2. NM_134865.3 → NP_608709.1  sorting nexin 21, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608709.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RT6, Q9VQG1
      Related
      FBpp0077416
      Conserved Domains (1) summary
      cd07279
      Location:71 → 188
      PX_SNX20_21_like; The phosphoinositide binding Phox Homology domain of Sorting Nexins 20 and 21
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBU4 M9PBU4
    Q9VQG1 Q9VQG1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools