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    Wwox WW domain containing oxidoreductase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34090, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wwoxprovided by FlyBase
    Official Full Name
    WW domain containing oxidoreductaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031972
    Locus tag
    Dmel_CG7221
    See related
    AllianceGenome:FB:FBgn0031972
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey177; CG7221; Dmel\CG7221; DmWWOX; WWOX
    Summary
    Involved in defense response to Gram-negative bacterium; regulation of reactive oxygen species metabolic process; and response to ionizing radiation. Located in cytoplasm. Is expressed in adult head and organism. Used to study cancer. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Wwox in Genome Data Viewer
    Location:
    28D3-28D3; 2-29 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7999670..8004286, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7999670..8004286, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene peste Neighboring gene antisense RNA:CR44996 Neighboring gene uncharacterized protein Neighboring gene Starvation-upregulated protein Neighboring gene Serpin 28Dc Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular Biology of the WWOX Gene That Spans Chromosomal Fragile Site FRA16D. Lee CS, et al. Cells, 2021 Jun 29. PMID 34210081, Free PMC Article
    2. FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila. O'Keefe LV, et al. Oncogene, 2005 Sep 29. PMID 16007179
    3. WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer. Richards RI, et al. Exp Biol Med (Maywood), 2015 Mar. PMID 25595186, Free PMC Article
    4. Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster. O'Keefe LV, et al. PLoS One, 2015. PMID 26302329, Free PMC Article
    5. Phosphoenolpyruvate Carboxykinase Maintains Glycolysis-driven Growth in Drosophila Tumors. Hussain R, et al. Sci Rep, 2017 Sep 14. PMID 28912546, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the ability of WWOX to facilitate escape from mitochondrial damage-induced glycolysis (Warburg effect) is, therefore, a plausible mechanism for its tumor suppressor activity.
      Title: Tumor suppressor WWOX moderates the mitochondrial respiratory complex.
    2. Together these results provide a molecular basis for the tumor suppressor functions of WWOX and the better prognosis observed in cancer patients with higher levels of WWOX activity.
      Title: Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster.
    3. Aberrant WWOX expression contributes to the altered metabolism in cancer.
      Title: WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer.
    4. study finds significant proportion of Wwox interactors have roles in aerobic metabolism; Wwox contributes to pathways involving aerobic metabolism and oxidative stress, providing an explanation for the 'non-classical tumour suppressor' behaviour of WWOX
      Title: Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species.
    5. the Drosophila orthologue of the human WWOX gene was identified. the protective function of DmWWOX in response to irradiation in Drosophila is conserved with human WWOX
      Title: FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WW domain containing oxidoreductase
    Names
    CG7221-PA
    CG7221-PB
    Wwox-PA
    Wwox-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7999670..8004286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298806.1 → NP_001285735.1  WW domain containing oxidoreductase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285735.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VLU5
      UniProtKB/TrEMBL
      X2J7F1
      Conserved Domains (3) summary
      cd09809
      Location:121 → 402
      human_WWOX_like_SDR_c-like; human WWOX (WW domain-containing oxidoreductase)-like, classical (c)-like SDRs
      smart00456
      Location:13 → 43
      WW; Domain with 2 conserved Trp (W) residues
      PRK06196
      Location:104 → 402
      PRK06196; oxidoreductase; Provisional

    2. NM_135327.4 → NP_609171.1  WW domain containing oxidoreductase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609171.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VLU5
      UniProtKB/TrEMBL
      X2J7F1
      Related
      FBpp0079172
      Conserved Domains (3) summary
      cd09809
      Location:121 → 402
      human_WWOX_like_SDR_c-like; human WWOX (WW domain-containing oxidoreductase)-like, classical (c)-like SDRs
      smart00456
      Location:13 → 43
      WW; Domain with 2 conserved Trp (W) residues
      PRK06196
      Location:104 → 402
      PRK06196; oxidoreductase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLU5.1 Q9VLU5
    X2J7F1 X2J7F1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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