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    Cyp4ad1 Cytochrome P450 4ad1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35821, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4ad1provided by FlyBase
    Official Full Name
    Cytochrome P450 4ad1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033292
    Locus tag
    Dmel_CG2110
    See related
    AllianceGenome:FB:FBgn0033292
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4ad1; BEST:LD02646; CG2110; Cyp4AD1; CYP4AD1; Dmel\CG2110
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; gonad; and organism. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4ad1 in Genome Data Viewer
    Location:
    44D1-44D1; 2-59 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8439395..8442806, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4326900..4330311, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Larval cuticle protein 3 Neighboring gene Larval cuticle protein 4 Neighboring gene Cytochrome P450 4e2 Neighboring gene mir-986 stem loop Neighboring gene Cytochrome P450 4e1 Neighboring gene Maltase A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and down-regulation of cytochrome P450 genes of the CYP4 family by ecdysteroid agonists in Spodoptera littoralis and Drosophila melanogaster. Davies L, et al. Insect Biochem Mol Biol, 2006 Oct. PMID 17027846
    2. Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster. Idda T, et al. Sci Rep, 2020 Dec 9. PMID 33299007, Free PMC Article
    3. Structural Modeling of Drosophila melanogaster Gut Cytochrome P450s and Docking Comparison of Fruit Fly Gut and Human Cytochrome P450s. Nirusimhan V, et al. Curr Drug Metab, 2022. PMID 35546755
    4. Phenotypic plasticity of the Drosophila transcriptome. Zhou S, et al. PLoS Genet, 2012. PMID 22479193, Free PMC Article
    5. Microarray analysis of Drosophila development during metamorphosis. White KP, et al. Science, 1999 Dec 10. PMID 10591654

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4ad1
    Names
    CG2110-PA
    CG2110-PB
    CYP4-related
    Cyp4ad1-PA
    Cyp4ad1-PB
    cytochrome P450
    NP_001260805.1
    NP_610380.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8439395..8442806 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136536.3 → NP_610380.1  cytochrome P450 4ad1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610380.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V4T3
      Related
      FBpp0087839
      Conserved Domains (1) summary
      pfam00067
      Location:36 → 470
      p450; Cytochrome P450

    2. NM_001273876.1 → NP_001260805.1  cytochrome P450 4ad1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UUE5
      Conserved Domains (1) summary
      cl12078
      Location:4 → 235
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H1UUE5 H1UUE5
    Q9V4T3.1 Q9V4T3

    Gene LinkOut

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