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    Galt Galactose-1-phosphate uridylyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33935, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Galtprovided by FlyBase
    Official Full Name
    Galactose-1-phosphate uridylyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263200
    Locus tag
    Dmel_CG9232
    See related
    AllianceGenome:FB:FBgn0263200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9232; dGALT; Dmel\CG9232; GALT
    Summary
    Enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity. Involved in UDP-galactose biosynthetic process; UDP-glucose metabolic process; and galactose catabolic process via UDP-galactose. Predicted to be active in cytosol. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; epithelium; and gut section. Used to study classic galactosemia and galactosemia. Human ortholog(s) of this gene implicated in classic galactosemia. Orthologous to human GALT (galactose-1-phosphate uridylyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Galt in Genome Data Viewer
    Location:
    26F6-26F6; 2-21 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6666264..6668033, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6666264..6668033, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ubiquitination factor E4A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cup Neighboring gene Serpin 27A Neighboring gene cortex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Restoring galactose metabolism without restoring GALT rescues both compromised survival in larvae and an adult climbing deficit in a GALT-null D. Melanogaster model of classic galactosemia. Daenzer JMI, et al. J Inherit Metab Dis, 2024 Sep. PMID 38960603,
    2. Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia. Jumbo-Lucioni PP, et al. Antioxid Redox Signal, 2014 May 20. PMID 23758052, Free PMC Article
    3. Memory, anticipation, action - working with Troy D. Zars. Wolf R, et al. J Neurogenet, 2020 Mar. PMID 32233838
    4. Oxidative stress contributes to outcome severity in a Drosophila melanogaster model of classic galactosemia. Jumbo-Lucioni PP, et al. Dis Model Mech, 2013 Jan. PMID 22773758, Free PMC Article
    5. Acute and long-term outcomes in a Drosophila melanogaster model of classic galactosemia occur independently of galactose-1-phosphate accumulation. Daenzer JM, et al. Dis Model Mech, 2016 Nov 1. PMID 27562100, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-D-galactose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in UDP-alpha-D-glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in UDP-galactose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in galactose catabolic process via UDP-galactose IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactose catabolic process via UDP-galactose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Galactose-1-phosphate uridylyltransferase
    Names
    CG9232-PA
    CG9232-PB
    Galt-PA
    Galt-PB
    galactose-1-phosphate uridyltransferase
    galactose-1-phosphate uridylyltransferase
    galactose-1P uridylyltransferase
    NP_001260142.1
    NP_609062.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6666264..6668033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135218.3 → NP_609062.2  Galactose-1-phosphate uridylyltransferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609062.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9EQS8, Q8SXN7, Q9VMA2
      UniProtKB/TrEMBL
      M9PB52
      Related
      FBpp0078951
      Conserved Domains (2) summary
      PRK11720
      Location:1 → 350
      PRK11720; galactose-1-phosphate uridylyltransferase; Provisional
      cd00608
      Location:10 → 341
      GalT; Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme ...

    2. NM_001273213.1 → NP_001260142.1  Galactose-1-phosphate uridylyltransferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260142.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9EQS8, Q8SXN7, Q9VMA2
      UniProtKB/TrEMBL
      M9PB52
      Conserved Domains (2) summary
      PRK11720
      Location:1 → 350
      PRK11720; galactose-1-phosphate uridylyltransferase; Provisional
      cd00608
      Location:10 → 341
      GalT; Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PB52 M9PB52
    Q9VMA2.2 Q9VMA2

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