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    eIF3d1 eukaryotic translation initiation factor 3 subunit d1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42789, updated on 17-Dec-2024

    Summary

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    Official Symbol
    eIF3d1provided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 3 subunit d1provided by FlyBase
    Primary source
    FLYBASE:FBgn0040227
    Locus tag
    Dmel_CG10161
    See related
    AllianceGenome:FB:FBgn0040227
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    153314_at; BEST:GM10514; CG10161; Dmel\CG10161; eIF-3p66; eIF3-S7; eIF3d; eiF3p66; eIF3p66; GM04979; GM10514
    Summary
    Enables translation initiation factor activity. Involved in regulation of translational initiation. Located in nucleus. Part of eukaryotic translation initiation factor 3 complex. Is expressed in adult head; adult heart; and organism. Orthologous to human EIF3D (eukaryotic translation initiation factor 3 subunit D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eIF3d1 in Genome Data Viewer
    Location:
    95A7-95A7; 3-80 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23680039..23682317)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19505761..19508039)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Gamma-interferon-inducible lysosomal thiol reductase 3 Neighboring gene Gamma-interferon-inducible lysosomal thiol reductase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Spatzle-Processing Enzyme

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hrp48 and eIF3d contribute to msl-2 mRNA translational repression. Szostak E, et al. Nucleic Acids Res, 2018 May 4. PMID 29635389, Free PMC Article
    2. eIF3j inhibits translation of a subset of circular RNAs in eukaryotic cells. Song Z, et al. Nucleic Acids Res, 2022 Nov 11. PMID 36330957, Free PMC Article
    3. Dissecting the roles of EIF4G homologs reveals DAP5 as a modifier of CGG repeat-associated toxicity in a Drosophila model of FXTAS. Malik I, et al. Neurobiol Dis, 2023 Aug. PMID 37352983, Free PMC Article
    4. A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing. Lu YX, et al. Elife, 2021 May 14. PMID 33988501, Free PMC Article
    5. The essential Drosophila ATP-binding cassette domain protein, pixie, binds the 40 S ribosome in an ATP-dependent manner and is required for translation initiation. Andersen DS, et al. J Biol Chem, 2007 May 18. PMID 17392269

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit d1
    Names
    CG10161-PB
    eIF-3p66
    eIF3d1-PB
    eukaryotic initiation factor 3 p66 subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23680039..23682317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079739.4 → NP_524463.2  eukaryotic translation initiation factor 3 subunit d1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524463.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NHP3, Q9VCK0
      Related
      FBpp0088565
      Conserved Domains (1) summary
      pfam05091
      Location:14 → 528
      eIF-3_zeta; Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRJ8 Q8MRJ8
    Q9VCK0.1 Q9VCK0

    Gene LinkOut

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