rols rolling pebbles [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rolsprovided by FlyBase
Official Full Name: rolling pebblesprovided by FlyBase
Primary source: FLYBASE:FBgn0041096
Locus tag: Dmel_CG32096
See related: AllianceGenome:FB:FBgn0041096
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0257455.19; ants; Ants; ANTS; ants/rols; CG12277; CG17155; CG32096; CG5679; Dmel\CG32096; l(3)08232; l(3)68Fd; l(3)j2A6; Rol/Ants; Rols; Rols6; rols7; Rols7; rols\ants
Summary: Enables cell adhesion molecule binding activity. A structural constituent of muscle. Involved in anterior Malpighian tubule development; border follicle cell migration; and striated muscle cell differentiation. Located in Z disc and apical plasma membrane. Colocalizes with cell-cell junction. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; gut section; muscle cell; and myoblast. Used to study intellectual developmental disorder with autistic features and language delay, with or without seizures. Human ortholog(s) of this gene implicated in intellectual developmental disorder with autistic features and language delay, with or without seizures. Orthologous to human TANC1 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1) and TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 68F1-68F1; 3-38 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12008225..12064859, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12001325..12057959, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

rols is expressed in glial cells, and its disruption affects behavioral outcomes.
Title: Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders.
Mhcl interacts with rolling pebbles 7 during myogenesis.
Title: Myosin heavy chain-like localizes at cell contact sites during Drosophila myoblast fusion and interacts in vitro with Rolling pebbles 7.
Results suggest an additive function of the intracellular domain of Duf and an early function of Rols and Loner which is independent of Duf.
Title: The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and Loner.
Genetic interaction of rols6, myoblast city protein, and rac GTP-binding proteins might lead to proper Malpighian tubule morphology.
Title: In Drosophila melanogaster, the rolling pebbles isoform 6 (Rols6) is essential for proper Malpighian tubule morphology.
This implicates the Duf-Rols7 positive feedback loop to the occurrence of fusion at specific sites along the membrane and provides a mechanism by which the rate of fusion is controlled.
Title: A positive feedback loop between Dumbfounded and Rolling pebbles leads to myotube enlargement in Drosophila.
In summary, these data show that besides the role in myoblast fusion, Rols7 is a scaffold protein during myofibrillogenesis and in the Z-line of the sarcomere as well as in the terminal Z-disc linking the muscle to the epidermal attachment sites.
Title: Drosophila rolling pebbles colocalises and putatively interacts with alpha-Actinin and the Sls isoform Zormin in the Z-discs of the sarcomere and with Dumbfounded/Kirre, alpha-Actinin and Zormin in the terminal Z-discs.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2130 (e-PCR)
- UniSTS:37650

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of muscle	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior Malpighian tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IDA Inferred from Direct Assay more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rolling pebbles

Names: CG32096-PA; CG32096-PB; CG32096-PC; CG32096-PD; CG32096-PE; CG32096-PF; CG32096-PG; CG32096-PH; CG32096-PI; antisocial; rolling pebbles 7; rols-PA; rols-PB; rols-PC; rols-PD; rols-PE; rols-PF; rols-PG; rols-PH; rols-PI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

12008225..12064859 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274810.1 → NP_001261739.1 rolling pebbles, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261739.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PC91, Q8WS24

Conserved Domains (7) summary

cd00204
Location:1447 → 1573

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00006
Location:1634 → 1666

TPR; TPR repeat [structural motif]

pfam12796
Location:1491 → 1583

Ank_2; Ankyrin repeats (3 copies)

pfam13414
Location:1634 → 1710

TPR_11; TPR repeat

pfam13857
Location:1261 → 1316

Ank_5; Ankyrin repeats (many copies)

pfam14634
Location:327 → 364

zf-RING_5; zinc-RING finger domain

sd00045
Location:1489 → 1517

ANK; ANK repeat [structural motif]
NM_001274808.1 → NP_001261737.1 rolling pebbles, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261737.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PF75, Q8WS24

Conserved Domains (7) summary

cd00204
Location:1448 → 1574

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00006
Location:1635 → 1667

TPR; TPR repeat [structural motif]

pfam12796
Location:1492 → 1584

Ank_2; Ankyrin repeats (3 copies)

pfam13414
Location:1635 → 1711

TPR_11; TPR repeat

pfam13857
Location:1262 → 1317

Ank_5; Ankyrin repeats (many copies)

pfam14634
Location:327 → 364

zf-RING_5; zinc-RING finger domain

sd00045
Location:1490 → 1518

ANK; ANK repeat [structural motif]
NM_168487.2 → NP_729778.1 rolling pebbles, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729778.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8WS24, Q9VTS9

Related

FBpp0075785

Conserved Domains (7) summary

cd00204
Location:1549 → 1675

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00006
Location:1736 → 1768

TPR; TPR repeat [structural motif]

pfam12796
Location:1593 → 1685

Ank_2; Ankyrin repeats (3 copies)

pfam13414
Location:1736 → 1812

TPR_11; TPR repeat

pfam13857
Location:1363 → 1418

Ank_5; Ankyrin repeats (many copies)

pfam14634
Location:327 → 364

zf-RING_5; zinc-RING finger domain

sd00045
Location:1591 → 1619

ANK; ANK repeat [structural motif]
NM_001274809.1 → NP_001261738.1 rolling pebbles, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261738.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PI28, Q8WTD1

Conserved Domains (7) summary

cd00204
Location:1217 → 1343

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00006
Location:1404 → 1436

TPR; TPR repeat [structural motif]

pfam12796
Location:1261 → 1353

Ank_2; Ankyrin repeats (3 copies)

pfam13414
Location:1404 → 1480

TPR_11; TPR repeat

pfam13857
Location:1031 → 1086

Ank_5; Ankyrin repeats (many copies)

pfam14634
Location:97 → 134

zf-RING_5; zinc-RING finger domain

sd00045
Location:1259 → 1287

ANK; ANK repeat [structural motif]
NM_168488.2 → NP_729779.1 rolling pebbles, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729779.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8WTD1, Q95NR3, Q9VTS8

Related

FBpp0075788

Conserved Domains (7) summary

cd00204
Location:1218 → 1344

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00006
Location:1405 → 1437

TPR; TPR repeat [structural motif]

pfam12796
Location:1262 → 1354

Ank_2; Ankyrin repeats (3 copies)

pfam13414
Location:1405 → 1481

TPR_11; TPR repeat

pfam13857
Location:1032 → 1087

Ank_5; Ankyrin repeats (many copies)

pfam14634
Location:97 → 134

zf-RING_5; zinc-RING finger domain

sd00045
Location:1260 → 1288

ANK; ANK repeat [structural motif]
NM_168489.2 → NP_729780.1 rolling pebbles, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729780.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8WS23, Q95V14, Q9VTS6

Related

FBpp0075789

Conserved Domains (7) summary

cd00204
Location:1319 → 1445

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00006
Location:1506 → 1538

TPR; TPR repeat [structural motif]

pfam00097
Location:97 → 134

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam12796
Location:1363 → 1455

Ank_2; Ankyrin repeats (3 copies)

pfam13414
Location:1506 → 1582

TPR_11; TPR repeat

pfam13857
Location:1133 → 1188

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:1361 → 1389

ANK; ANK repeat [structural motif]
NM_001274807.1 → NP_001261736.1 rolling pebbles, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261736.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFC6, Q8WS23

Conserved Domains (7) summary

cd00204
Location:1318 → 1444

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00006
Location:1505 → 1537

TPR; TPR repeat [structural motif]

pfam00097
Location:97 → 134

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam12796
Location:1362 → 1454

Ank_2; Ankyrin repeats (3 copies)

pfam13414
Location:1505 → 1581

TPR_11; TPR repeat

pfam13857
Location:1132 → 1187

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:1360 → 1388

ANK; ANK repeat [structural motif]
NM_168490.2 → NP_729781.1 rolling pebbles, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729781.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8WS23, Q95V14, Q9VTS6

Related

FBpp0075787

Conserved Domains (7) summary

cd00204
Location:1319 → 1445

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00006
Location:1506 → 1538

TPR; TPR repeat [structural motif]

pfam00097
Location:97 → 134

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam12796
Location:1363 → 1455

Ank_2; Ankyrin repeats (3 copies)

pfam13414
Location:1506 → 1582

TPR_11; TPR repeat

pfam13857
Location:1133 → 1188

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:1361 → 1389

ANK; ANK repeat [structural motif]
NM_140285.3 → NP_648542.1 rolling pebbles, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648542.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8WTD1, Q95NR3, Q9VTS8

Related

FBpp0075786

Conserved Domains (7) summary

cd00204
Location:1218 → 1344

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00006
Location:1405 → 1437

TPR; TPR repeat [structural motif]

pfam12796
Location:1262 → 1354

Ank_2; Ankyrin repeats (3 copies)

pfam13414
Location:1405 → 1481

TPR_11; TPR repeat

pfam13857
Location:1032 → 1087

Ank_5; Ankyrin repeats (many copies)

pfam14634
Location:97 → 134

zf-RING_5; zinc-RING finger domain

sd00045
Location:1260 → 1288

ANK; ANK repeat [structural motif]

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
M9PC91		M9PC91
M9PF75		M9PF75
M9PFC6		M9PFC6
M9PI28		M9PI28
Q8WS23		Q8WS23
Q8WS24		Q8WS24
Q8WTD1		Q8WTD1
Q8WTD2		Q8WTD2
Q9VTS6		Q9VTS6
Q9VTS8		Q9VTS8
Q9VTS9		Q9VTS9