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    CtsL3 Cathepsin L3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CtsL3provided by FlyBase
    Official Full Name
    Cathepsin L3provided by FlyBase
    Primary source
    FLYBASE:FBgn0037396
    Locus tag
    Dmel_CG11459
    See related
    AllianceGenome:FB:FBgn0037396
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11459; CTS L; Cts5; Dmel\CG11459
    Summary
    Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Orthologous to human CTSH (cathepsin H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CtsL3 in Genome Data Viewer
    Location:
    83D2-83D2; 3-47.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6025826..6027238, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1851548..1852960, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rm62 Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene long non-coding RNA:CR46221

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A unique cluster of roo insertions in the promoter region of a stress response gene in Drosophila melanogaster. Merenciano M, et al. Mob DNA, 2019. PMID 30911338, Free PMC Article
    2. Structural and functional conservation profiles of novel cathepsin L-like proteins identified in the Drosophila melanogaster genome. Kumar S, et al. J Biomol Struct Dyn, 2013 Dec. PMID 23256878
    3. Integrative genome-wide analysis of dopaminergic neuron-specific PARIS expression in Drosophila dissects recognition of multiple PPAR-γ associated gene regulation. Yazar V, et al. Sci Rep, 2021 Nov 2. PMID 34728675, Free PMC Article
    4. The Circulating Protease Persephone Is an Immune Sensor for Microbial Proteolytic Activities Upstream of the Drosophila Toll Pathway. Issa N, et al. Mol Cell, 2018 Feb 15. PMID 29452635, Free PMC Article
    5. Functional proteomics of the active cysteine protease content in Drosophila S2 cells. Kocks C, et al. Mol Cell Proteomics, 2003 Nov. PMID 13130081

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cathepsin L3
    Names
    CG11459-PA
    CG11459-PB
    CtsL3-PA
    CtsL3-PB
    NP_001287191.1
    NP_649608.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6025826..6027238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300262.1 → NP_001287191.1  cathepsin L3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287191.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNK6
      Conserved Domains (2) summary
      cd02248
      Location:120 → 334
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
      pfam08246
      Location:30 → 85
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

    2. NM_141351.3 → NP_649608.1  cathepsin L3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNK6
      Related
      FBpp0078272
      Conserved Domains (2) summary
      cd02248
      Location:120 → 334
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
      pfam08246
      Location:30 → 85
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNK6 Q9VNK6

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