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    Pdhb Pyruvate dehydrogenase E1 beta subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43437, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pdhbprovided by FlyBase
    Official Full Name
    Pyruvate dehydrogenase E1 beta subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039635
    Locus tag
    Dmel_CG11876
    See related
    AllianceGenome:FB:FBgn0039635
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG 11876; CG11876; Dmel\CG11876; dPDHB; E1beta; Pdh; PDHB; PDHbeta; PDHE1beta
    Summary
    Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; gut section; and mesoderm. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHB (pyruvate dehydrogenase E1 subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Pdhb in Genome Data Viewer
    Location:
    98F10-98F10; 3-97 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29113071..29116197)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24938793..24941919)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene BRD4 interacting chromatin remodeling complex associated protein Neighboring gene long non-coding RNA:CR45030 Neighboring gene alpha-Mannosidase class I b Neighboring gene Autophagy-related 14 Neighboring gene yemanuclein Neighboring gene Choline transporter-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuron-specific knockdown of Drosophila PDHB induces reduction of lifespan, deficient locomotive ability, abnormal morphology of motor neuron terminals and photoreceptor axon targeting. Dung VM, et al. Exp Cell Res, 2018 May 15. PMID 29501567
    2. Probiotic Lactobacillus spp. improves Drosophila memory by increasing lactate dehydrogenase levels in the brain mushroom body neurons. Ho SM, et al. Gut Microbes, 2024 Jan-Dec. PMID 38372783, Free PMC Article
    3. A comprehensive approach to determining BER capacities and their change with aging in Drosophila melanogaster mitochondria by oligonucleotide microarray. Garreau-Balandier I, et al. FEBS Lett, 2014 May 2. PMID 24642371
    4. Identification of CR43467 encoding a long non-coding RNA as a novel genetic interactant with dFIG4, a CMT-causing gene. Shimada S, et al. Exp Cell Res, 2020 Jan 1. PMID 31704059
    5. Stem Cell Intrinsic Hexosamine Metabolism Regulates Intestinal Adaptation to Nutrient Content. Mattila J, et al. Dev Cell, 2018 Oct 8. PMID 30220570, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to pyruvate dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to pyruvate dehydrogenase (acetyl-transferring) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in acetyl-CoA biosynthetic process from pyruvate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of pyruvate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pyruvate dehydrogenase E1 beta subunit
    Names
    CG11876-PA
    CG11876-PB
    CG11876-PC
    CG11876-PD
    Pdhb-PA
    Pdhb-PB
    Pdhb-PC
    Pdhb-PD
    pyruvate dehydrogenase E1 component subunit beta
    pyruvate dehydrogenase E1beta subunit
    NP_651668.1
    NP_733265.1
    NP_733266.1
    NP_733267.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29113071..29116197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170386.2 → NP_733265.1  pyruvate dehydrogenase E1 beta subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733265.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K5K3, Q8IGJ4, Q8IML6
      Related
      FBpp0084735
      Conserved Domains (3) summary
      cd07036
      Location:33 → 199
      TPP_PYR_E1-PDHc-beta_like; Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins
      PLN02683
      Location:2 → 352
      PLN02683; pyruvate dehydrogenase E1 component subunit beta
      pfam02780
      Location:222 → 340
      Transketolase_C; Transketolase, C-terminal domain

    2. NM_170388.2 → NP_733267.1  pyruvate dehydrogenase E1 beta subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733267.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IML6
      Related
      FBpp0084736
      Conserved Domains (1) summary
      cl11410
      Location:33 → 118
      TPP_enzyme_PYR; Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes

    3. NM_170387.2 → NP_733266.1  pyruvate dehydrogenase E1 beta subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733266.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IML6
      Related
      FBpp0084737
      Conserved Domains (1) summary
      cl11410
      Location:33 → 118
      TPP_enzyme_PYR; Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes

    4. NM_143411.4 → NP_651668.1  pyruvate dehydrogenase E1 beta subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651668.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K5K3, Q8IGJ4, Q8IML6
      Related
      FBpp0084738
      Conserved Domains (3) summary
      cd07036
      Location:33 → 199
      TPP_PYR_E1-PDHc-beta_like; Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins
      PLN02683
      Location:2 → 352
      PLN02683; pyruvate dehydrogenase E1 component subunit beta
      pfam02780
      Location:222 → 340
      Transketolase_C; Transketolase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K5K3.1 Q7K5K3

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