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    Mal-A5 Maltase A5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35828, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Mal-A5provided by FlyBase
    Official Full Name
    Maltase A5provided by FlyBase
    Primary source
    FLYBASE:FBgn0050359
    Locus tag
    Dmel_CG30359
    See related
    AllianceGenome:FB:FBgn0050359
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG30359; CG8689; Dmel\CG30359; Drome_A5; Mal-5b; mal_A5
    Summary
    Predicted to enable alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mal-A5 in Genome Data Viewer
    Location:
    44D1-44D1; 2-59 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8462753..8465092)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4350258..4352597)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Maltase A3 Neighboring gene Maltase A4 Neighboring gene Maltase A6 Neighboring gene Maltase A7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Association between duplicated maltase genes and the transcriptional regulation for the carbohydrate changes in Drosophila melanogaster. Inomata N, et al. Gene, 2019 Feb 20. PMID 30399425
    2. Ameliorative effect of bayberry leaves proanthocyanidins on high sugar diet induced Drosophila melanogaster. Wang M, et al. Front Pharmacol, 2022. PMID 36188544, Free PMC Article
    3. Assessment of genome-wide protein function classification for Drosophila melanogaster. Mi H, et al. Genome Res, 2003 Sep. PMID 12952880, Free PMC Article
    4. Transforming growth factor β/activin signaling functions as a sugar-sensing feedback loop to regulate digestive enzyme expression. Chng WA, et al. Cell Rep, 2014 Oct 9. PMID 25284780
    5. Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Grönke S, et al. Cell Metab, 2005 May. PMID 16054079

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-1,4-glucosidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    maltase A5
    Names
    CG30359-PA
    CG30359-PB
    CG30359-PC
    Mal-A5-PA
    Mal-A5-PB
    Mal-A5-PC
    NP_001163088.1
    NP_001286197.1
    NP_610382.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8462753..8465092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169617.2 → NP_001163088.1  maltase A5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163088.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0N3
      Conserved Domains (2) summary
      cd11328
      Location:1 → 418
      AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
      pfam00128
      Location:1 → 325
      Alpha-amylase; Alpha amylase, catalytic domain

    2. NM_136538.4 → NP_610382.2  maltase A5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610382.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U124
      Related
      FBpp0087828
      Conserved Domains (2) summary
      cd11328
      Location:41 → 514
      AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
      pfam00128
      Location:67 → 421
      Alpha-amylase; Alpha amylase, catalytic domain

    3. NM_001299268.1 → NP_001286197.1  maltase A5, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286197.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEU9
      Conserved Domains (2) summary
      cd11328
      Location:41 → 495
      AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
      pfam00128
      Location:67 → 421
      Alpha-amylase; Alpha amylase, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LEU9 A0A0B4LEU9
    Q5U124 Q5U124
    Q8T0N3 Q8T0N3

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