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    Pus1 Pseudouridine synthase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42440, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pus1provided by FlyBase
    Official Full Name
    Pseudouridine synthase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038811
    Locus tag
    Dmel_CG4159
    See related
    AllianceGenome:FB:FBgn0038811
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4159; Dmel\CG4159; PUS1
    Summary
    Predicted to enable pseudouridine synthase activity. Predicted to be involved in mRNA pseudouridine synthesis and tRNA pseudouridine synthesis. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 1. Orthologous to human PUS1 (pseudouridine synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pus1 in Genome Data Viewer
    Location:
    92F2-92F2; 3-69 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20591024..20592671, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16416746..16418393, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46044 Neighboring gene Septin 2 Neighboring gene Signal recognition particle 72 Neighboring gene bonus Neighboring gene transfer RNA:Leucine-TAA 1-1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dual nature of pseudouridylation in U2 snRNA: Pus1p-dependent and Pus1p-independent activities in yeasts and higher eukaryotes. Deryusheva S, et al. RNA, 2017 Jul. PMID 28432181, Free PMC Article
    2. Transcriptome-wide analysis of pseudouridylation in Drosophila melanogaster. Song W, et al. G3 (Bethesda), 2023 Mar 9. PMID 36534986, Free PMC Article
    3. Nucleotide modifications in messenger RNA and their role in development and disease. Dezi V, et al. Biochem Soc Trans, 2016 Oct 15. PMID 27911721
    4. H/ACA snRNP-dependent ribosome biogenesis regulates translation of polyglutamine proteins. Breznak SM, et al. Sci Adv, 2023 Jun 23. PMID 37343092, Free PMC Article
    5. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudouridine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pseudouridine synthesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pseudouridine synthase 1
    Names
    CG4159-PA
    CG4159-PB
    Pus1-PA
    Pus1-PB
    pseudouridylate synthase 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20591024..20592671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142642.2 → NP_650899.1  pseudouridine synthase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650899.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UUC7, Q9VDK6
      Related
      FBpp0083351
      Conserved Domains (2) summary
      cd02568
      Location:74 → 325
      PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
      COG0101
      Location:70 → 330
      TruA; tRNA U38,U39,U40 pseudouridine synthase TruA [Translation, ribosomal structure and biogenesis]

    2. NM_001170193.1 → NP_001163664.1  pseudouridine synthase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163664.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIR1, H1UUC7
      Conserved Domains (2) summary
      cd02568
      Location:106 → 357
      PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like
      COG0101
      Location:102 → 362
      TruA; tRNA U38,U39,U40 pseudouridine synthase TruA [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIR1 E1JIR1
    Q9VDK6 Q9VDK6

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