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    CG6966 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41816, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6966provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038286
    Locus tag
    Dmel_CG6966
    See related
    AllianceGenome:FB:FBgn0038286
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT05246; dFEM1A; Dmel\CG6966
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of ubiquitin-protein transferase activity. Predicted to be part of ubiquitin ligase complex. Orthologous to human FEM1A (fem-1 homolog A) and FEM1C (fem-1 homolog C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6966 in Genome Data Viewer
    Location:
    88E1-88E1; 3-56 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15079320..15095631, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10905042..10921353, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene defective proboscis extension response 9 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-2493 stem loop Neighboring gene antisense RNA:CR45600 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of New Regulators of the Oocyte-to-Embryo Transition in Drosophila. Avilés-Pagán EE, et al. G3 (Bethesda), 2020 Sep 2. PMID 32690584, Free PMC Article
    2. FEM1 proteins are ancient regulators of SLBP degradation. Dankert JF, et al. Cell Cycle, 2017 Mar 19. PMID 28118078, Free PMC Article
    3. Evaluation of the genomic extent of effects of fixed inversion differences on intraspecific variation and interspecific gene flow in Drosophila pseudoobscura and D. persimilis. Machado CA, et al. Genetics, 2007 Mar. PMID 17179068, Free PMC Article
    4. An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila. Li-Kroeger D, et al. Elife, 2018 Aug 9. PMID 30091705, Free PMC Article
    5. Microgravity simulation by diamagnetic levitation: effects of a strong gradient magnetic field on the transcriptional profile of Drosophila melanogaster. Herranz R, et al. BMC Genomics, 2012 Feb 1. PMID 22296880, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6966-PB
    CG6966-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15079320..15095631 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300404.1 → NP_001287333.1  uncharacterized protein Dmel_CG6966, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287333.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IG97, Q8T4I2, Q9VFD5
      UniProtKB/TrEMBL
      A0A0B4LI92
      Conserved Domains (4) summary
      cd00204
      Location:110 → 234
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:87 → 177
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:182 → 234
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:118 → 146
      ANK; ANK repeat [structural motif]

    2. NM_001104326.2 → NP_001097796.1  uncharacterized protein Dmel_CG6966, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097796.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IG97, Q8T4I2, Q9VFD5
      UniProtKB/TrEMBL
      A0A0B4LI92
      Conserved Domains (4) summary
      cd00204
      Location:110 → 234
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:87 → 177
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:182 → 234
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:118 → 146
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LI92 A0A0B4LI92
    Q9VFD5.2 Q9VFD5

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