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    Ppm1 Ppm1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38071, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppm1provided by FlyBase
    Official Full Name
    Ppm1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035143
    Locus tag
    Dmel_CG12169
    See related
    AllianceGenome:FB:FBgn0035143
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12169; Dmel\CG12169; dPPM1; PP2C; PPM1
    Summary
    Predicted to enable phosphoprotein phosphatase activity. Predicted to be involved in signal transduction. Is expressed in adult head. Orthologous to human PPM1N (protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ppm1 in Genome Data Viewer
    Location:
    61C5-61C5; 3-0.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (581337..582810)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (581337..582810)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46249 Neighboring gene Homeodomain interacting protein kinase Neighboring gene long non-coding RNA:CR45808 Neighboring gene Kahuli Neighboring gene Mediator complex subunit 14 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Knockdown of genes involved in axonal transport enhances the toxicity of human neuromuscular disease-linked MATR3 mutations in Drosophila. Zhao M, et al. FEBS Lett, 2020 Sep. PMID 32515490
    2. A collective form of cell death requires homeodomain interacting protein kinase. Link N, et al. J Cell Biol, 2007 Aug 13. PMID 17682052, Free PMC Article
    3. An RNAi Screen To Identify Protein Phosphatases That Function Within the Drosophila Circadian Clock. Agrawal P, et al. G3 (Bethesda), 2016 Dec 7. PMID 27784754, Free PMC Article
    4. Transgenic Drosophila lines for LexA-dependent gene and growth regulation. Chang KR, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100369, Free PMC Article
    5. How Genetics Has Helped Piece Together the MAPK Signaling Pathway. Ashton-Beaucage D, et al. Methods Mol Biol, 2017. PMID 27924555

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Ppm1
    Names
    CG12169-PA
    Ppm1-PA
    NP_612039.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      581337..582810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138195.2 → NP_612039.1  Ppm1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612039.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0Q0
      Related
      FBpp0072452, FBtr0072553
      Conserved Domains (1) summary
      cd00143
      Location:22 → 286
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0Q0 Q9W0Q0

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