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    CG17266 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35571, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17266provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033089
    Locus tag
    Dmel_CG17266
    See related
    AllianceGenome:FB:FBgn0033089
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG17266
    Summary
    Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Part of precatalytic spliceosome. Is expressed in adult head and spermatogonium. Orthologous to human PPIH (peptidylprolyl isomerase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17266 in Genome Data Viewer
    Location:
    42C4-42C4; 2-55 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6675028..6676001, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2562533..2563506, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Heparan sulfate C5-epimerase Neighboring gene Post-GPI attachment to proteins 3 Neighboring gene Ribonuclease P/MRP subunit p25 Neighboring gene Tyrosine decarboxylase 1 Neighboring gene long non-coding RNA:CR44164

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two functional but noncomplementing Drosophila tyrosine decarboxylase genes: distinct roles for neural tyramine and octopamine in female fertility. Cole SH, et al. J Biol Chem, 2005 Apr 15. PMID 15691831
    2. The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. Abramczuk MK, et al. Development, 2017 Nov 1. PMID 28935704
    3. The Drosophila retinoblastoma binding protein 6 family member has two isoforms and is potentially involved in embryonic patterning. Hull R, et al. Int J Mol Sci, 2015 May 6. PMID 25955646, Free PMC Article
    4. DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells. Tarayrah-Ibraheim L, et al. Nat Commun, 2021 Apr 16. PMID 33863891, Free PMC Article
    5. The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting. Liang D, et al. Mol Cell, 2017 Dec 7. PMID 29174924, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17266-PA
    CG17266-PB
    PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
    NP_001246149.1
    NP_610224.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6675028..6676001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136380.3 → NP_610224.1  uncharacterized protein Dmel_CG17266, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610224.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5H1
      Related
      FBpp0085477
      Conserved Domains (1) summary
      cd01926
      Location:17 → 181
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

    2. NM_001259220.2 → NP_001246149.1  uncharacterized protein Dmel_CG17266, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246149.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5H1
      Conserved Domains (1) summary
      cd01926
      Location:17 → 181
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V5H1 Q4V5H1

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