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    CG10700 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35183, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG10700provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032754
    Locus tag
    Dmel_CG10700
    See related
    AllianceGenome:FB:FBgn0032754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10700
    Summary
    Predicted to enable oxidoreductase activity, acting on NAD(P)H. Predicted to be involved in execution phase of apoptosis. Predicted to be located in endoplasmic reticulum and mitochondrial inner membrane. Predicted to be active in cytoplasm. Orthologous to human AIFM3 (apoptosis inducing factor mitochondria associated 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10700 in Genome Data Viewer
    Location:
    37B13-37B13; 2-54 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19077276..19079028, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19077276..19079028, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Lim3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44905

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene structure of Drosophila diaphorase-1: diversity of transcripts in adult males and females, in different organs and at different stages of development. Ivanova PM, et al. J Genet, 2008 Aug. PMID 18776642
    2. Molecular cloning and characterization of a human AIF-like gene with ability to induce apoptosis. Xie Q, et al. J Biol Chem, 2005 May 20. PMID 15764604
    3. Functional Analysis of Forkhead Transcription Factor Fd59a in the Spermatogenesis of Drosophila melanogaster. Tang T, et al. Insects, 2024 Jun 27. PMID 39057213, Free PMC Article
    4. Identification of genes underlying hypoxia tolerance in Drosophila by a P-element screen. Azad P, et al. G3 (Bethesda), 2012 Oct. PMID 23050227, Free PMC Article
    5. New genes often acquire male-specific functions but rarely become essential in Drosophila. Kondo S, et al. Genes Dev, 2017 Sep 15. PMID 29051389, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in execution phase of apoptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10700-PA
    NP_609942.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19077276..19079028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136098.2 → NP_609942.1  uncharacterized protein Dmel_CG10700 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609942.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5T4, Q9VJ03
      Related
      FBpp0080714
      Conserved Domains (5) summary
      COG3393
      Location:336 → 508
      COG3393; Predicted acetyltransferase, GNAT family [General function prediction only]
      cd03478
      Location:10 → 106
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam00070
      Location:273 → 350
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:135 → 414
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:464 → 527
      Reductase_C; Reductase C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJ03 Q9VJ03

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