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    ACXA Adenylyl cyclase X A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53432, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ACXAprovided by FlyBase
    Official Full Name
    Adenylyl cyclase X Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040510
    Locus tag
    Dmel_CG17176
    See related
    AllianceGenome:FB:FBgn0040510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AC; Ac62D; AC62D; CG17176; DACXA; Dmel\CG17176
    Summary
    Predicted to enable adenylate cyclase activity. Involved in spermatogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head; organism; pre-elongation spermatid; and spermatocyte. Orthologous to human ADCY2 (adenylate cyclase 2) and ADCY7 (adenylate cyclase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ACXA in Genome Data Viewer
    Location:
    34A2-34A2; 2-47 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12921091..12925453)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12921091..12925453)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Adenylyl cyclase X C Neighboring gene Adenylyl cyclase X B Neighboring gene Adenylyl cyclase X E Neighboring gene long non-coding RNA:CR44183

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila learning and memory gene rutabaga encodes a Ca2+/Calmodulin-responsive adenylyl cyclase. Levin LR, et al. Cell, 1992 Feb 7. PMID 1739965
    2. A quantitative study of the Ca2+/calmodulin sensitivity of adenylyl cyclase in Aplysia, Drosophila, and rat. Yovell Y, et al. J Neurochem, 1992 Nov. PMID 1402918
    3. Restricted expression of a truncated adenylyl cyclase in the cephalic furrow of Drosophila melanogaster. Cann MJ, et al. Dev Genes Evol, 2000 Jan. PMID 10603085
    4. Voltage-gated calcium channels act upstream of adenylyl cyclase Ac78C to promote timely initiation of dendrite regeneration. Hertzler JI, et al. PLoS Genet, 2024 Aug. PMID 39186815, Free PMC Article
    5. A new family of adenylyl cyclase genes in the male germline of Drosophila melanogaster. Cann MJ, et al. Dev Genes Evol, 2000 Apr. PMID 11180822

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenylyl cyclase X A
    Names
    ACXA-PA
    ACXA-PC
    ACXA-PD
    ACXA-PG
    ACXA-PH
    AdenylateCyclase A
    CG17176-PA
    CG17176-PC
    CG17176-PD
    CG17176-PG
    CG17176-PH
    adenylyl cyclase
    adenylyl cyclase 62D
    NP_001246011.1
    NP_001246012.1
    NP_001260423.1
    NP_001285883.1
    NP_620475.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12921091..12925453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273494.1 → NP_001260423.1  adenylyl cyclase X A, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260423.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBA8
      Conserved Domains (3) summary
      smart00044
      Location:262 → 464
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam16214
      Location:42 → 291
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      cl11967
      Location:306 → 489
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

    2. NM_138990.2 → NP_620475.2  adenylyl cyclase X A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_620475.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NJA2, Q9VK51
      Related
      FBpp0079996, FBtr0080415
      Conserved Domains (3) summary
      smart00044
      Location:262 → 464
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam16214
      Location:42 → 291
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      cl11967
      Location:306 → 489
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

    3. NM_001259082.1 → NP_001246011.1  adenylyl cyclase X A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246011.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDN7, Q9NJA2
      Conserved Domains (3) summary
      smart00044
      Location:262 → 464
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam16214
      Location:42 → 291
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      cl11967
      Location:306 → 489
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

    4. NM_001259083.1 → NP_001246012.1  adenylyl cyclase X A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246012.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NF12
      Conserved Domains (2) summary
      cd07302
      Location:310 → 433
      CHD; cyclase homology domain
      pfam16214
      Location:42 → 291
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    5. NM_001298954.1 → NP_001285883.1  adenylyl cyclase X A, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285883.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JAA1
      Conserved Domains (2) summary
      pfam16214
      Location:42 → 291
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      cl11967
      Location:306 → 394
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDN7 M9NDN7
    M9NF12 M9NF12
    M9PBA8 M9PBA8
    Q8MZ70 Q8MZ70
    Q9NJA2 Q9NJA2
    Q9VK51 Q9VK51
    X2JAA1 X2JAA1

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