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    Hers Histone gene-specific Epigenetic Repressor in late S phase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33000, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hersprovided by FlyBase
    Official Full Name
    Histone gene-specific Epigenetic Repressor in late S phaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052529
    Locus tag
    Dmel_CG32529
    See related
    AllianceGenome:FB:FBgn0052529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11936; CG15619; CG32529; Dmel\CG32529; HERS
    Summary
    Enables transcription cis-regulatory region binding activity. Involved in heterochromatin formation. Predicted to be part of chromatin silencing complex. Is expressed in spermatozoon; wing hinge primordium; and wing pouch. Orthologous to human BAHD1 (bromo adjacent homology domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hers in Genome Data Viewer
    Location:
    18F4-19A2; 1-64 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19866146..19908108)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19760179..19802141)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nucleoporin 205kD Neighboring gene THADA Neighboring gene amnesiac Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epigenetic silencing of core histone genes by HERS in Drosophila. Ito S, et al. Mol Cell, 2012 Feb 24. PMID 22365829
    2. Drosophila FMRP controls miR-276-mediated regulation of nejire mRNA for space-filling dendrite development. Li H, et al. G3 (Bethesda), 2022 Nov 4. PMID 36102801, Free PMC Article
    3. Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity. Campbell JL, et al. J Neurogenet, 2009. PMID 19863272, Free PMC Article
    4. Heterochromatic silencing of immune-related genes in glia is required for BBB integrity and normal lifespan in drosophila. Shu S, et al. Aging Cell, 2023 Oct. PMID 37594178, Free PMC Article
    5. Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body. Duronio RJ, et al. RNA Biol, 2017 Jun 3. PMID 28059623, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin silencing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histone gene-specific epigenetic repressor in late S phase
    Names
    CG32529-PA
    CG32529-PC
    CG32529-PD
    CG32529-PE
    CG32529-PF
    CG32529-PG
    CG32529-PH
    CG32529-PI
    Hers-PA
    Hers-PC
    Hers-PD
    Hers-PE
    Hers-PF
    Hers-PG
    Hers-PH
    Hers-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19866146..19908108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272807.1 → NP_001259736.1  histone gene-specific epigenetic repressor in late S phase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259736.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NN1, Q9VWC0
      Conserved Domains (1) summary
      cd04714
      Location:2366 → 2519
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

    2. NM_134516.3 → NP_608360.2  histone gene-specific epigenetic repressor in late S phase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608360.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NN1, Q9VWC0
      Related
      FBpp0074569
      Conserved Domains (1) summary
      cd04714
      Location:2366 → 2519
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

    3. NM_001258842.1 → NP_001245771.1  histone gene-specific epigenetic repressor in late S phase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245771.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NN1, Q9VWC0
      Conserved Domains (1) summary
      cd04714
      Location:2366 → 2519
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

    4. NM_001258843.1 → NP_001245772.1  histone gene-specific epigenetic repressor in late S phase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245772.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2MGL2
      Conserved Domains (1) summary
      cd04714
      Location:1293 → 1446
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

    5. NM_001038766.3 → NP_001033855.1  histone gene-specific epigenetic repressor in late S phase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033855.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2MGL2
      Conserved Domains (1) summary
      cd04714
      Location:1293 → 1446
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

    6. NM_001258844.1 → NP_001245773.1  histone gene-specific epigenetic repressor in late S phase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245773.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2MGL2
      Conserved Domains (1) summary
      cd04714
      Location:1293 → 1446
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

    7. NM_167688.2 → NP_728309.1  histone gene-specific epigenetic repressor in late S phase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728309.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWC2
      Related
      FBpp0074570
      Conserved Domains (1) summary
      cd04714
      Location:1117 → 1270
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

    8. NM_001258845.1 → NP_001245774.1  histone gene-specific epigenetic repressor in late S phase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245774.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NES5, Q95U13
      Conserved Domains (1) summary
      cd04714
      Location:976 → 1129
      BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NES5 M9NES5
    Q2MGL2 Q2MGL2
    Q5BI54 Q5BI54
    Q86NN1 Q86NN1
    Q95U13 Q95U13
    Q9VWC0 Q9VWC0
    Q9VWC2 Q9VWC2

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