zld zelda [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: zldprovided by FlyBase
Official Full Name: zeldaprovided by FlyBase
Primary source: FLYBASE:FBgn0259789
Locus tag: Dmel_CG12701
See related: AllianceGenome:FB:FBgn0259789
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12701; Dmel\CG12701; EP1344; l(1)G0225; l(1)G0353; l(1)G0427; vfl; Vfl; VFL; Zelda; Zld; ZLD
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding activity; and nucleosome binding activity. Involved in several processes, including miRNA transcription; positive regulation of gastrulation; and regulation of gene expression. Located in chromatin and nucleoplasm. Is active in nucleus. Is expressed in several structures, including cuboidal/columnar epithelium; germ layer; glial cell; sensory nervous system primordium; and unpaired neurons. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 18F1-18F2; 1-64 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19766465..19783548, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19660498..19677581, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multi-level regulation of even-skipped stripes by the ubiquitous factor Zelda.
Title: Multi-level regulation of even-skipped stripes by the ubiquitous factor Zelda.
CLAMP regulates zygotic genome activation in Drosophila embryos.
Title: CLAMP regulates zygotic genome activation in Drosophila embryos.
Cell-type-specific chromatin occupancy by the pioneer factor Zelda drives key developmental transitions in Drosophila.
Title: Cell-type-specific chromatin occupancy by the pioneer factor Zelda drives key developmental transitions in Drosophila.
Exploring a Drosophila Transcription Factor Interaction Network to Identify Cis-Regulatory Modules.
Title: Exploring a Drosophila Transcription Factor Interaction Network to Identify Cis-Regulatory Modules.
CLAMP and Zelda function together to promote Drosophila zygotic genome activation.
Title: CLAMP and Zelda function together to promote Drosophila zygotic genome activation.
Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during early Drosophila development.
Title: Cis-regulatory chromatin loops arise before TADs and gene activation, and are independent of cell fate during early Drosophila development.
We conclude that in B. germanica, Zelda strictly activates the zygotic genome, within the MZT, a role conserved in more derived endopterygote insects. In B. germanica, zelda is expressed during MZT, whereas in D. melanogaster and T. castaneum it is expressed beyond this transition.
Title: Zelda and the maternal-to-zygotic transition in cockroaches.
Zld modifies probability of transcriptional activation, the timing of this activation, and the rate at which transcription occurs. This effective rate increase is due to an increased accumulation of Dl at the site of transcription, suggesting that transcription factor "hubs" induced by Zld functionally regulate transcription.
Title: The Drosophila Pioneer Factor Zelda Modulates the Nuclear Microenvironment of a Dorsal Target Enhancer to Potentiate Transcriptional Output.
Continued Zelda activity is required throughout genome activation. Zelda binds DNA in the context of nucleosomes and suggest that this allows Zelda to occupy the genome despite the rapid division cycles in the early embryo.
Title: Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation.
Study reports that Drosophila protein Jumu binds N6-methyladenine (6mA)-marked DNA and acts as a maternal factor to regulate the maternal-to-zygotic transition and finds that zelda encoding the pioneer factor Zelda is marked by 6mA. Genetic assays suggest that Jumu controls the proper zygotic genome activation in early embryos, at least in part, by regulating zelda expression.
Title: 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin loop anchoring activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleosome binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellularization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in maternal mRNA clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in maternal-to-zygotic transition of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast fate commitment	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleosome organization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zelda

Names: CG12701-PA; CG12701-PB; CG12701-PD; CG12701-PF; CG12701-PG; EP1344; ZELDA; lethal (1) G0225; lethal (1) G0353; lethal (1) G0427; vielfaltig; vielfaltig/Zelda; zinc-finger early drosophila activator; zld-PA; zld-PB; zld-PD; zld-PF; zld-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

19766465..19783548 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258840.3 → NP_001245769.1 zelda, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245769.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7YU17

Conserved Domains (1) summary

pfam12171
Location:552 → 577

zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
NM_001258839.2 → NP_001245768.1 zelda, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245768.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7YU17

Conserved Domains (1) summary

pfam12171
Location:552 → 577

zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
NM_167685.3 → NP_728304.1 zelda, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728304.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9NES1, Q9VWC6, X2BZL0

UniProtKB/TrEMBL

Q7YU17

Related

FBpp0074576

Conserved Domains (5) summary

cd08368
Location:1328 → 1389

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

sd00017
Location:1357 → 1377

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:1413 → 1435

zf-C2H2; Zinc finger, C2H2 type

pfam12171
Location:552 → 577

zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

pfam13465
Location:1398 → 1422

zf-H2C2_2; Zinc-finger double domain
NM_134512.5 → NP_608356.1 zelda, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608356.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9NES1, Q9VWC6, X2BZL0

UniProtKB/TrEMBL

Q7YU17

Related

FBpp0074577

Conserved Domains (5) summary

cd08368
Location:1328 → 1389

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

sd00017
Location:1357 → 1377

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:1413 → 1435

zf-C2H2; Zinc finger, C2H2 type

pfam12171
Location:552 → 577

zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

pfam13465
Location:1398 → 1422

zf-H2C2_2; Zinc-finger double domain
NM_001298537.1 → NP_001285466.1 zelda, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285466.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9NES1, Q9VWC6, X2BZL0

UniProtKB/TrEMBL

Q7YU17

Conserved Domains (5) summary

cd08368
Location:1328 → 1389

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

sd00017
Location:1357 → 1377

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:1413 → 1435

zf-C2H2; Zinc finger, C2H2 type

pfam12171
Location:552 → 577

zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

pfam13465
Location:1398 → 1422

zf-H2C2_2; Zinc-finger double domain