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    Muc11A Mucin 11A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32174, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Muc11Aprovided by FlyBase
    Official Full Name
    Mucin 11Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052656
    Locus tag
    Dmel_CG32656
    See related
    AllianceGenome:FB:FBgn0052656
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2779; CG32656; Dmel\CG32656
    Summary
    Predicted to be an extracellular matrix structural constituent. Predicted to be located in extracellular matrix. Is expressed in several structures, including embryonic epipharynx; embryonic head epidermis; embryonic hypopharynx; embryonic/larval fat body; and embryonic/larval proventriculus. Human ortholog(s) of this gene implicated in several diseases, including biliary tract benign neoplasm; dry eye syndrome; familial juvenile hyperuricemic nephropathy; mucinous adenocarcinoma; and pancreatic cancer (multiple). Orthologous to human MUC1 (mucin 1, cell surface associated). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Muc11A in Genome Data Viewer
    Location:
    11A2-11A3; 1-38 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12059795..12065144)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11953828..11959177)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43960 Neighboring gene Cytochrome P450 318a1 Neighboring gene long non-coding RNA:CR43961 Neighboring gene Tenascin accessory Neighboring gene Uch-L5-related Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential splicing of the lectin domain of an O-glycosyltransferase modulates both peptide and glycopeptide preferences. May C, et al. J Biol Chem, 2020 Aug 28. PMID 32669364, Free PMC Article
    2. Induced transcription results in local changes in chromatin structure, replication timing, and DNA polytenization in a site of intercalary heterochromatin. Koryakov DE, et al. Chromosoma, 2012 Dec. PMID 23015267
    3. A potential role for Drosophila mucins in development and physiology. Syed ZA, et al. PLoS One, 2008 Aug 22. PMID 18725942, Free PMC Article
    4. Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway. Jones RM, et al. Cell Rep, 2015 Aug 25. PMID 26279578, Free PMC Article
    5. Genomic variation in natural populations of Drosophila melanogaster. Langley CH, et al. Genetics, 2012 Oct. PMID 22673804, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular matrix structural constituent ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mucin 11A
    Names
    CG32656-PB
    Muc11A-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12059795..12065144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298221.1 → NP_001285150.1  mucin 11A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285150.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JBD0
      Conserved Domains (2) summary
      PRK07764
      Location:696 → 1109
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam01607
      Location:1495 → 1547
      CBM_14; Chitin binding Peritrophin-A domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JXX2 Q7JXX2
    X2JBD0 X2JBD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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