Actbeta Activin-beta [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Actbetaprovided by FlyBase
Official Full Name: Activin-betaprovided by FlyBase
Primary source: FLYBASE:FBgn0024913
Locus tag: Dmel_CG11062
See related: AllianceGenome:FB:FBgn0024913
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: act; Act; Act-beta; ACTB; actbeta; activin; Activin; activin-beta; anon-WO02059370.79; beta-Activin; CG11062; dact; dAct; dACT; dActbeta; dActivin; Dmel\CG11062
Summary: Predicted to enable cytokine activity. Involved in several processes, including nervous system development; positive regulation of imaginal disc growth; and positive regulation of neuroblast proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including epithelial cell; ganglia; inner photoreceptor cell; male germline cell; and presumptive embryonic/larval system. Orthologous to several human genes including INHBA (inhibin subunit beta A); INHBB (inhibin subunit beta B); and INHBC (inhibin subunit beta C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 102F8-102F8; 4-0 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (1077331..1084796, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (1097957..1105422, complement)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activin is a neural inducer of a male-specific muscle in Drosophila.
Title: Activin is a neural inducer of a male-specific muscle in Drosophila.
TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.
Title: TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.
Actbeta is a positive regulator of muscle mass that is directly delivered to muscles by motoneurons.
Title: Body Size and Tissue-Scaling Is Regulated by Motoneuron-Derived Activinß in Drosophila melanogaster.
The authors find that both arms of the TFGb signaling pathways specifically instruct the pale photoreceptor subset in R8. The Activin arm utilizes the three ligands dActb, Daw, and Myo non-redundantly to activate Babo and downstream dSmad2 in R8, while the BMP arm signals by way of Dpp and Gbb to Tkv and Mad.
Title: Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochastic Drosophila retina.
a conserved role for activin in enhancing adipokinetic hormone/glucagon signaling and glycemic control, is reported.
Title: Midgut-Derived Activin Regulates Glucagon-like Action in the Fat Body and Glycemic Control.
Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction
Title: Anterograde Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction.
These data reveal how insulin signaling can regulate aging through control of Activin signaling that in turn controls autophagy, representing a potentially conserved molecular basis for longevity assurance
Title: Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila.
These results suggest that the Activin signaling pathway is required for producing the proper number of neurons to enable normal connection of incoming photoreceptor axons to their targets.
Title: Drosophila Activin- and the Activin-like product Dawdle function redundantly to regulate proliferation in the larval brain.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in R8 cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in activin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in activin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of imaginal disc-derived wing size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse structure or activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Activin-beta

Names: Actbeta-PA; CG11062-PA; DmActivin-beta; activan; activin; activin 102F; activin beta; activin-b; activinbeta; dActivin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004353.4 Reference assembly

Range

1077331..1084796 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143685.3 → NP_651942.2 Activin-beta [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651942.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O61643, Q8MRB1, Q8WR60, Q9V497

Related

FBpp0088273

Conserved Domains (2) summary

pfam00019
Location:843 → 945

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:370 → 509

TGFb_propeptide; TGF-beta propeptide