Prosalpha4 Proteasome alpha4 subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Prosalpha4provided by FlyBase
Official Full Name: Proteasome alpha4 subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0004066
Locus tag: Dmel_CG3422
See related: AllianceGenome:FB:FBgn0004066
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 28.1Pros; 3422; a4; alpha-4; Alpha-4; alpha4; alpha4_dm; CG3422; Dmel\CG3422; PROS-28.1; Pros-Dm28.1; PROS-Dm28.1; Pros28; pros28.1; Pros28.1; PROSA-28.1; PSA4_DROME
Summary: Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; germline cell; imaginal disc; and mesoderm. Orthologous to human PSMA7 (proteasome 20S subunit alpha 7) and PSMA8 (proteasome 20S subunit alpha 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (16276270..16277587)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (16170303..16171620)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
NOT enables peptidase activity	IKR Inferred from Key Residues more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IC Inferred by Curator more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	ISS Inferred from Sequence or Structural Similarity more info

Names: 20s proteasome; CG3422-PA; Prosalpha4-PA; alpha-subunit of 20S proteasome; alpha4; proteasome 28kD subunit 1

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