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    spz6 spatzle 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37956, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spz6provided by FlyBase
    Official Full Name
    spatzle 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0035056
    Locus tag
    Dmel_CG9196
    See related
    AllianceGenome:FB:FBgn0035056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LP10725; CG9196; CT26280; Dmel\CG9196; Spz-6; Spz6
    Summary
    Enables Toll binding activity. Predicted to be involved in central nervous system formation and innate immune response. Located in extracellular space. Is expressed in embryonic head; embryonic/larval epidermis; embryonic/larval hindgut; and embryonic/larval tracheal section. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See spz6 in Genome Data Viewer
    Location:
    60E1-60E1; 2-107 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24757378..24760466)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20644901..20647989)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44828 Neighboring gene Ubiquitin specific protease 15/31 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutathione S transferase E12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A family of proteins related to Spätzle, the toll receptor ligand, are encoded in the Drosophila genome. Parker JS, et al. Proteins, 2001 Oct 1. PMID 11536362
    2. Evolutionary and functional epitopes of the Spätzle protein: new insights into activation of the Toll receptor. Wang Y, et al. Cell Mol Life Sci, 2009 May. PMID 19308321, Free PMC Article
    3. Large-Scale Transgenic Drosophila Resource Collections for Loss- and Gain-of-Function Studies. Zirin J, et al. Genetics, 2020 Apr. PMID 32071193, Free PMC Article
    4. The Taiman Transcriptional Coactivator Engages Toll Signals to Promote Apoptosis and Intertissue Invasion in Drosophila. Byun PK, et al. Curr Biol, 2019 Sep 9. PMID 31402304, Free PMC Article
    5. Spz/Toll-6 signal guides organotropic metastasis in Drosophila. Mishra-Gorur K, et al. Dis Model Mech, 2019 Oct 7. PMID 31477571, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Toll binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Toll binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spatzle 6
    Names
    CG9196-PA
    spatzle6
    spz6-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24757378..24760466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138117.3 → NP_611961.1  spatzle 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611961.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W116
      Related
      FBpp0072277
      Conserved Domains (1) summary
      pfam16077
      Location:256 → 407
      Spaetzle; Spaetzle
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MQZ4 Q8MQZ4
    Q9W116 Q9W116

    Gene LinkOut

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