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    brat brain tumor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35197, updated on 14-Nov-2024

    Summary

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    Official Symbol
    bratprovided by FlyBase
    Official Full Name
    brain tumorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010300
    Locus tag
    Dmel_CG10719
    See related
    AllianceGenome:FB:FBgn0010300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-37CDa; Brat; BRAT; Cf; CG10719; Dmel\CG10719; E60; fs(2)ltoPM43; l(2)37Cf; l(2)brat; l(2)E60; lincRNA.S1565
    Summary
    Enables mRNA 3'-UTR binding activity and translation repressor activity. Involved in several processes, including ganglion mother cell fate determination; negative regulation of neuroblast proliferation; and nervous system development. Located in several cellular components, including apical cortex; basal cortex; and neuronal cell body. Is expressed in several structures, including CNS glial cell; anlage in statu nascendi; germline cell; head epidermis primordium; and ventral nerve cord. Used to study brain cancer; cancer; and neurodegenerative disease. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See brat in Genome Data Viewer
    Location:
    37C1-37C6; 2-54 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19133816..19179758)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19133816..19179758)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Dynactin 6, p27 subunit Neighboring gene Asparaginyl-tRNA synthetase Neighboring gene RNA polymerase I and III subunit D Neighboring gene long non-coding RNA:CR44977 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptome and proteome quantification of a tumor model provides novel insights into post-transcriptional gene regulation. Jüschke C, et al. Genome Biol, 2013 Nov 30. PMID 24289286, Free PMC Article
    2. Model of the brain tumor-Pumilio translation repressor complex. Edwards TA, et al. Genes Dev, 2003 Oct 15. PMID 14561773, Free PMC Article
    3. Crystal structure of the coiled-coil domain of Drosophila TRIM protein Brat. Liu C, et al. Proteins, 2019 Aug. PMID 30958583
    4. The genetic and molecular organization of the dense cluster of functionally related, vital genes in the DOPA decarboxylase region of the Drosophila melanogaster genome. Wright TR. Results Probl Cell Differ, 1987. PMID 3112881
    5. Mei-P26 mediates tissue-specific responses to the Brat tumor suppressor and the dMyc proto-oncogene in Drosophila. Ferreira A, et al. Genetics, 2014 Sep. PMID 24990993, Free PMC Article

    See all (327) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regenerative growth is constrained by brain tumor to ensure proper patterning in Drosophila.
      Title: Regenerative growth is constrained by brain tumor to ensure proper patterning in Drosophila.
    2. Simultaneous activation of Tor and suppression of ribosome biogenesis by TRIM-NHL proteins promotes terminal differentiation.
      Title: Simultaneous activation of Tor and suppression of ribosome biogenesis by TRIM-NHL proteins promotes terminal differentiation.
    3. The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in the Drosophila female germline and the early embryo.
      Title: The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in the Drosophila female germline and the early embryo.
    4. Structure and dynamics of the quaternary hunchback mRNA translation repression complex.
      Title: Structure and dynamics of the quaternary hunchback mRNA translation repression complex.
    5. This study determined the crystal structure of Brat-CC domain (aa 376-511) at 2.5 A, showing that Brat-CC forms an elongated antiparallel dimer through an unconventional CC structure.
      Title: Crystal structure of the coiled-coil domain of Drosophila TRIM protein Brat.
    6. The tumor suppressor Brat controls neuronal stem cell lineages by inhibiting Deadpan and Zelda.
      Title: The tumor suppressor Brat controls neuronal stem cell lineages by inhibiting Deadpan and Zelda.
    7. Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor proteins has been described.
      Title: Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor Proteins.
    8. Data suggest that brain tumor protein (Brat) promotes midline crossing through directing the localization or stability of Adenomatous polyposis coli-2 (Apc2) at the plus ends of microtubules in navigating commissural axons.
      Title: Brain Tumor promotes axon growth across the midline through interactions with the microtubule stabilizing protein Apc2.
    9. results support a novel role for Brat/TRIM3 in maintaining stem cell equilibrium and suppressing tumor growth by regulating NICD nuclear transport
      Title: Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport.
    10. BRAT is a prominent post-transcriptional regulator in the early embryo through mechanisms that are largely independent of PUM.
      Title: Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 19147425-19154402 mobile_element_type = transposon:297{}407

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation regulator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation repressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in asymmetric neuroblast division resulting in ganglion mother cell formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ganglion mother cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis HMP PubMed 
    involved_in rRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in segmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    located_in apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basal cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    brain tumor
    Names
    CG10719-PA
    CG10719-PB
    CG10719-PC
    CG10719-PE
    CG10719-PF
    brain tumour
    brat-PA
    brat-PB
    brat-PC
    brat-PE
    brat-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19133816..19179758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201913.2 → NP_001188842.2  brain tumor, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188842.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSJ1
      Conserved Domains (3) summary
      smart00336
      Location:176 → 222
      BBOX; B-Box-type zinc finger
      cd14959
      Location:760 → 1030
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
      pfam00643
      Location:328 → 366
      zf-B_box; B-box zinc finger

    2. NM_057597.4 → NP_476945.1  brain tumor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476945.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0U9, Q0E8P2, Q2XXZ6, Q8MQJ9, Q8MR02, Q9U633, Q9U634, Q9U635, Q9U636, Q9Y1W4
      UniProtKB/TrEMBL
      E8NHB3
      Related
      FBpp0080702
      Conserved Domains (3) summary
      smart00336
      Location:176 → 222
      BBOX; B-Box-type zinc finger
      cd14959
      Location:760 → 1030
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
      pfam00643
      Location:328 → 366
      zf-B_box; B-box zinc finger

    3. NM_206004.2 → NP_995726.1  brain tumor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995726.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0U9, Q0E8P2, Q2XXZ6, Q8MQJ9, Q8MR02, Q9U633, Q9U634, Q9U635, Q9U636, Q9Y1W4
      UniProtKB/TrEMBL
      E8NHB3
      Conserved Domains (3) summary
      smart00336
      Location:176 → 222
      BBOX; B-Box-type zinc finger
      cd14959
      Location:760 → 1030
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
      pfam00643
      Location:328 → 366
      zf-B_box; B-box zinc finger

    4. NM_134302.2 → NP_599129.1  brain tumor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599129.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0U9, Q0E8P2, Q2XXZ6, Q8MQJ9, Q8MR02, Q9U633, Q9U634, Q9U635, Q9U636, Q9Y1W4
      UniProtKB/TrEMBL
      E8NHB3
      Related
      FBpp0080703
      Conserved Domains (3) summary
      smart00336
      Location:176 → 222
      BBOX; B-Box-type zinc finger
      cd14959
      Location:760 → 1030
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
      pfam00643
      Location:328 → 366
      zf-B_box; B-box zinc finger

    5. NM_001299154.1 → NP_001286083.1  brain tumor, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286083.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V0U9, Q0E8P2, Q2XXZ6, Q8MQJ9, Q8MR02, Q9U633, Q9U634, Q9U635, Q9U636, Q9Y1W4
      UniProtKB/TrEMBL
      E8NHB3
      Conserved Domains (3) summary
      smart00336
      Location:176 → 222
      BBOX; B-Box-type zinc finger
      cd14959
      Location:760 → 1030
      NHL_brat_like; NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins
      pfam00643
      Location:328 → 366
      zf-B_box; B-box zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E8NHB3 E8NHB3
    M9MSJ1 M9MSJ1
    Q8MQJ9.2 Q8MQJ9

    Gene LinkOut

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