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    Jarid2 Jumonji, AT rich interactive domain 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39103, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jarid2provided by FlyBase
    Official Full Name
    Jumonji, AT rich interactive domain 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036004
    Locus tag
    Dmel_CG3654
    See related
    AllianceGenome:FB:FBgn0036004
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3654; dJARID2; djmj; dJmj; Dmel\CG3654; jarid2; JARID2; l(3)j2B8
    Summary
    Predicted to enable DNA binding activity. Involved in chromatin remodeling and positive regulation of DNA-templated transcription. Located in euchromatin and nucleus. Is expressed in embryonic brain; embryonic/larval midgut; larval ventral nerve cord; organism; and spermatozoon. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human JARID2 (jumonji and AT-rich interaction domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Jarid2 in Genome Data Viewer
    Location:
    67B9-67B10; 3-29 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9477038..9486530)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9470138..9479630)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ubiquitin carboxy-terminal hydrolase L5 Neighboring gene pallbearer Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of dJmj differentially affects intestinal stem cells and differentiated enterocytes. Suong DNA, et al. Cell Signal, 2018 Jan. PMID 29102770
    2. Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation. Sanulli S, et al. Mol Cell, 2015 Mar 5. PMID 25620564, Free PMC Article
    3. Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease. Basu M, et al. JCI Insight, 2017 Oct 19. PMID 29046480, Free PMC Article
    4. The effects of genetic background on exercise performance in Drosophila. Damschroder D, et al. Fly (Austin), 2020 Mar-Dec. PMID 33100141, Free PMC Article
    5. Ex vivo genome-wide RNAi screening of the Drosophila Toll signaling pathway elicited by a larva-derived tissue extract. Kanoh H, et al. Biochem Biophys Res Commun, 2015 Nov 13. PMID 26427875

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of dJmj differentially affects intestinal stem cells and differentiated enterocytes.
      Title: Overexpression of dJmj differentially affects intestinal stem cells and differentiated enterocytes.
    2. in vivo studies with Jarid2 mutants in flies demonstrate that among several histone modifications tested, only methylation of histone 3 at K27 (H3K27), the mark implemented by PRC2, was affected
      Title: Polycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables histone demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables histone demethylase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables histone demethylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Jumonji, AT rich interactive domain 2
    Names
    CG3654-PD
    Jarid2-PD
    Jumonji, AT-rich interactive domain 2
    jumonji

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9477038..9486530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140067.2 → NP_648324.1  Jumonji, AT rich interactive domain 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648324.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VT00
      Related
      FBpp0076196
      Conserved Domains (4) summary
      smart00545
      Location:1740 → 1781
      JmjN; Small domain found in the jumonji family of transcription factors
      pfam02373
      Location:2066 → 2181
      JmjC; JmjC domain, hydroxylase
      pfam01388
      Location:1812 → 1893
      ARID; ARID/BRIGHT DNA binding domain
      pfam02928
      Location:2281 → 2334
      zf-C5HC2; C5HC2 zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AWH4 Q6AWH4
    Q8SXP6 Q8SXP6
    Q9VT00 Q9VT00

    Gene LinkOut

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