dsx doublesex [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dsxprovided by FlyBase
Official Full Name: doublesexprovided by FlyBase
Primary source: FLYBASE:FBgn0000504
Locus tag: Dmel_CG11094
See related: AllianceGenome:FB:FBgn0000504
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11094; Dmdsx; Dmel\CG11094; Dsx; DSX; dsxF; DSXF; dsxM; DSXM; Hr; ix-62c
Summary: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; protein homodimerization activity; and zinc ion binding activity. Involved in axon midline choice point recognition; imaginal disc-derived genitalia development; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including adult doublesex neurons; adult muscle cell; imaginal disc; organism subdivision; and sense organ. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 84E5-84E6; 3-48 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (7924323..7967408, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (3750045..3793130, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The doublesex gene regulates dimorphic sexual and aggressive behaviors in Drosophila.
Title: The doublesex gene regulates dimorphic sexual and aggressive behaviors in Drosophila.
From fruitless to sex: On the generation and diversification of an innate behavior.
Title: From fruitless to sex: On the generation and diversification of an innate behavior.
Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons.
Title: Sex-determining genes distinctly regulate courtship capability and target preference via sexually dimorphic neurons.
Sequential activation of Notch and Grainyhead gives apoptotic competence to Abdominal-B expressing larval neuroblasts in Drosophila Central nervous system.
Title: Sequential activation of Notch and Grainyhead gives apoptotic competence to Abdominal-B expressing larval neuroblasts in Drosophila Central nervous system.
The mosaic of sexually dimorphic and monomorphic organs depends on modular regulation of dsx transcription by dedicated cell type-specific enhancers.
Title: Modular tissue-specific regulation of doublesex underpins sexually dimorphic development in Drosophila.
Dsx acts to 'tip the balance' between the male or female programs, which are then executed independently of dsx.
Title: Doublesex controls specification and maintenance of the gonad stem cell niches in Drosophila.
The capacity of Abdominal-B to use the sex-specific isoform of Dsx as a cofactor underlines the possibility that these two classes of protein are capable of cooperating in selection and regulation of target genes in a tissue- and sex-specific manner
Title: The Hox gene Abdominal-B uses Doublesex(F) as a cofactor to promote neuroblast apoptosis in the Drosophila central nervous system.
Identification of the Doublesex protein binding sites that activate expression of lozenge in the female genital disc in Drosophila melanogaster has been reported.
Title: Identification of the Doublesex protein binding sites that activate expression of lozenge in the female genital disc in Drosophila melanogaster.
The sex determination genes fruitless and doublesex, and a sex-specific P1-DN1 neuronal feedback govern the interaction between sleep and sexual behavior.
Title: Genetic and neuronal mechanisms governing the sex-specific interaction between sleep and sexual behaviors in Drosophila.
Sex differences in Drosophila somatic gene expression controlled by variation and regulation by doublesex have been scrutinized.
Title: Sex Differences in Drosophila Somatic Gene Expression: Variation and Regulation by doublesex.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c7947820-7947788 mobile_element_type = transposon:gtwin{}1846

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axon midline choice point recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in courtship behavior	NAS Non-traceable Author Statement more info	PubMed
involved_in female analia development	NAS Non-traceable Author Statement more info	PubMed
involved_in female sex differentiation	TAS Traceable Author Statement more info	PubMed
involved_in female somatic sex determination	TAS Traceable Author Statement more info	PubMed
involved_in genital disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived female genitalia development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in imaginal disc-derived female genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived male genitalia development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in male analia development	NAS Non-traceable Author Statement more info	PubMed
involved_in male courtship behavior	TAS Traceable Author Statement more info	PubMed
involved_in male courtship behavior, veined wing generated song production	TAS Traceable Author Statement more info	PubMed
involved_in male sex differentiation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of developmental pigmentation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex comb development	TAS Traceable Author Statement more info	PubMed
involved_in sex determination	TAS Traceable Author Statement more info	PubMed
involved_in sex differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sex-specific pigmentation	TAS Traceable Author Statement more info	PubMed
involved_in somatic sex determination	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: doublesex

Names: CG11094-PA; CG11094-PB; CG11094-PC; CG11094-PD; CG11094-PE; CG11094-PF; CG11094-PG; double sex; dsx-PA; dsx-PB; dsx-PC; dsx-PD; dsx-PE; dsx-PF; dsx-PG; hermaphrodite; intersex-62c

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

7924323..7967408 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169202.1 → NP_731197.1 doublesex, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731197.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P23022, P23023, Q0KIA7, Q95TA5, Q9VHY0

UniProtKB/TrEMBL

A0A0B4KFS4

Related

FBpp0081256, FBtr0081759

Conserved Domains (2) summary

pfam00751
Location:41 → 86

DM; DM DNA binding domain

pfam08828
Location:353 → 404

DSX_dimer; Doublesex dimerization domain
NM_001275424.1 → NP_001262353.1 doublesex, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262353.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGR7

Conserved Domains (2) summary

pfam00751
Location:41 → 86

DM; DM DNA binding domain

pfam08828
Location:353 → 404

DSX_dimer; Doublesex dimerization domain
NM_001275423.1 → NP_001262352.1 doublesex, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262352.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P23022, P23023, Q0KIA7, Q95TA5, Q9VHY0

UniProtKB/TrEMBL

A0A0B4KFS4

Conserved Domains (2) summary

pfam00751
Location:41 → 86

DM; DM DNA binding domain

pfam08828
Location:353 → 404

DSX_dimer; Doublesex dimerization domain
NM_001300291.1 → NP_001287220.1 doublesex, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287220.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGS9

Conserved Domains (2) summary

pfam00751
Location:41 → 86

DM; DM DNA binding domain

pfam08828
Location:353 → 412

DSX_dimer; Doublesex dimerization domain
NM_169203.2 → NP_731198.1 doublesex, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731198.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGS9

Related

FBpp0081257

Conserved Domains (2) summary

pfam00751
Location:41 → 86

DM; DM DNA binding domain

pfam08828
Location:353 → 412

DSX_dimer; Doublesex dimerization domain
NM_001426709.1 → NP_001413640.1 doublesex, isoform G [Drosophila melanogaster]

Status: REVIEWED
NM_079548.5 → NP_524272.4 doublesex, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524272.4

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGS9

Related

FBpp0081258

Conserved Domains (2) summary

pfam00751
Location:41 → 86

DM; DM DNA binding domain

pfam08828
Location:353 → 412

DSX_dimer; Doublesex dimerization domain