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    Tollo tollo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44497, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tolloprovided by FlyBase
    Official Full Name
    tolloprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029114
    Locus tag
    Dmel_CG6890
    See related
    AllianceGenome:FB:FBgn0029114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6890; CT21344; Dmel\CG6890; dTLR8; dToll8; Tl-8; toll; TOLL 8; Toll-8; Toll8; tollo; tollo/toll-8
    Summary
    Enables receptor ligand activity. Involved in several processes, including convergent extension; peripheral nervous system neuron development; and regulation of protein glycosylation. Is active in plasma membrane. Is expressed in several structures, including cuboidal/columnar epithelium; embryonic head; gut section; imaginal disc; and neurogenic region. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tollo in Genome Data Viewer
    Location:
    71C1-71C1; 3-43 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15235619..15242832)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15228719..15235932)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44562 Neighboring gene Peroxiredoxin 1 Neighboring gene Bestrophin 4 Neighboring gene Bestrophin 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic developmental elaboration of N-linked glycan complexity in the Drosophila melanogaster embryo. Aoki K, et al. J Biol Chem, 2007 Mar 23. PMID 17264077
    2. Induction of neuron-specific glycosylation by Tollo/Toll-8, a Drosophila Toll-like receptor expressed in non-neural cells. Seppo A, et al. Development, 2003 Apr. PMID 12588858
    3. SARM: From immune regulator to cell executioner. Carty M, et al. Biochem Pharmacol, 2019 Mar. PMID 30633870
    4. Computational identification and experimental characterization of preferred downstream positions in human core promoters. Dreos R, et al. PLoS Comput Biol, 2021 Aug. PMID 34383743, Free PMC Article
    5. Three key subregions contribute to the function of the downstream RNA polymerase II core promoter. Theisen JW, et al. Mol Cell Biol, 2010 Jul. PMID 20457814, Free PMC Article

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry.
      Title: Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry.
    2. Tollo expression in the motoneuron is both necessary and sufficient for regulating neuromuscular junction growth.
      Title: Retrograde neurotrophin signaling through Tollo regulates synaptic growth in Drosophila.
    3. findings show Toll-8 (Tollo) plays an important role in controlling the respiratory epithelium immune response; data indicate that, by antagonizing the IMD pathway, Tollo is preventing over-activation of the antibacterial response in the airway epithelium
      Title: Toll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium.
    4. Ectopic expression of Tollo/Toll-8 antagonizes Dpp signaling and induces cell sorting in the Drosophila wing.
      Title: Ectopic expression of Tollo/Toll-8 antagonizes Dpp signaling and induces cell sorting in the Drosophila wing.
    5. tollo/toll-8 signaling influences flux through several processing steps that affect the maturation of N-linked glycans
      Title: Dynamic developmental elaboration of N-linked glycan complexity in the Drosophila melanogaster embryo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables receptor ligand activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axis elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in convergent extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peripheral nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tollo
    Names
    CG6890-PA
    Toll-8
    Tollo-PA
    toll receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15235619..15242832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080018.2 → NP_524757.1  tollo [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524757.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2XXW0, Q9V477
      Related
      FBpp0075360
      Conserved Domains (5) summary
      smart00255
      Location:1076 → 1211
      TIR; Toll - interleukin 1 - resistance
      COG4886
      Location:210 → 656
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:276 → 558
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:260 → 283
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:815 → 875
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V477.1 Q9V477

    Gene LinkOut

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