U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG5521 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43242, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG5521provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039466
    Locus tag
    Dmel_CG5521
    See related
    AllianceGenome:FB:FBgn0039466
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5521; EP3527; FBpp0084441
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to several human genes including RALGAPA2 (Ral GTPase activating protein catalytic subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG5521 in Genome Data Viewer
    Location:
    97D11-97D12; 3-92 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26966930..26977878)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22792652..22803600)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Tetraspanin 97E Neighboring gene Gustatory receptor 97a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Evolution of the Ras-like small GTPases and their regulators. van Dam TJ, et al. Small GTPases, 2011 Jan. PMID 21686276, Free PMC Article
    2. Evolutionary expansion of the Ras switch regulatory module in eukaryotes. Díez D, et al. Nucleic Acids Res, 2011 Jul. PMID 21447561, Free PMC Article
    3. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. Wendler F, et al. EMBO J, 2010 Jan 20. PMID 19942856, Free PMC Article
    4. A gain-of-function screen for genes controlling motor axon guidance and synaptogenesis in Drosophila. Kraut R, et al. Curr Biol, 2001 Mar 20. PMID 11301252
    5. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Bernards A. Biochim Biophys Acta, 2003 Mar 17. PMID 12618308

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG5521-PA
    CG5521-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26966930..26977878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170277.2 → NP_001163748.1  uncharacterized protein Dmel_CG5521, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163748.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIZ3
      Conserved Domains (1) summary
      pfam02145
      Location:1648 → 1820
      Rap_GAP; Rap/ran-GAP

    2. NM_143259.3 → NP_651516.1  uncharacterized protein Dmel_CG5521, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651516.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q058W5, Q9VB98
      Related
      FBpp0084441
      Conserved Domains (1) summary
      pfam02145
      Location:1642 → 1814
      Rap_GAP; Rap/ran-GAP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIZ3 E1JIZ3
    Q9VB98.2 Q9VB98

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous