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    GNBP1 Gram-negative bacteria binding protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40034, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GNBP1provided by FlyBase
    Official Full Name
    Gram-negative bacteria binding protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0040323
    Locus tag
    Dmel_CG6895
    See related
    AllianceGenome:FB:FBgn0040323
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6895; DGNBP-1; DGNBP1; Dmel\CG6895; GNBP; GNBP 1; GNBP-1
    Summary
    Enables several functions, including (1->3)-beta-D-glucan binding activity; lipopolysaccharide binding activity; and peptidoglycan binding activity. Involved in several processes, including Toll receptor ligand protein activation cascade; defense response to Gram-positive bacterium; and peptidoglycan catabolic process. Located in extracellular space and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GNBP1 in Genome Data Viewer
    Location:
    75D6-75D6; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18675800..18677876)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18668900..18670976)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Caprin Neighboring gene Gram-negative bacteria binding protein 2 Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure. Lee SH, et al. Protein Sci, 2006 Feb. PMID 16385003, Free PMC Article
    2. Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA. Wang L, et al. EMBO J, 2006 Oct 18. PMID 17024181, Free PMC Article
    3. Evolution of the βGRP/GNBP/β-1,3-glucanase family of insects. Hughes AL. Immunogenetics, 2012 Jul. PMID 22410636
    4. Wall teichoic acids of Staphylococcus aureus limit recognition by the drosophila peptidoglycan recognition protein-SA to promote pathogenicity. Atilano ML, et al. PLoS Pathog, 2011 Dec. PMID 22144903, Free PMC Article
    5. Clustering of peptidoglycan recognition protein-SA is required for sensing lysine-type peptidoglycan in insects. Park JW, et al. Proc Natl Acad Sci U S A, 2007 Apr 17. PMID 17409189, Free PMC Article

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results demonstrate that GNBP1 and PGRP-SA can jointly activate the Toll pathway
      Title: Dual activation of the Drosophila toll pathway by two pattern recognition receptors.
    2. GNBP1 acts upstream of the Toll ligand Spatzle and works in the defense against Gram-positive bacterial infection in Drosophila
      Title: In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults.
    3. GNBP1 presents a processed form of peptidoglycan for sensing by PGRP-SA and that a tripartite interaction between these proteins and peptidoglycan is essential for downstream signaling.
      Title: Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables (1->3)-beta-D-glucan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables beta-glucanase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables hydrolase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pattern recognition receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pattern recognition receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Toll receptor ligand protein activation cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Toll receptor ligand protein activation cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in innate immune response-activating signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pattern recognition receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidoglycan catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Gram-negative bacteria binding protein 1
    Names
    CG6895-PA
    GNBP1-PA
    glucan-binding protein 1
    gram-negative binding protein 1
    osiris

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18675800..18677876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079418.3 → NP_524142.2  Gram-negative bacteria binding protein 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524142.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0ZX67, A0ZX68, A0ZX72
      Related
      FBpp0074817
      Conserved Domains (2) summary
      cd02179
      Location:175 → 491
      GH16_beta_GRP; beta-1,3-glucan recognition protein, member of glycosyl hydrolase family 16
      pfam15886
      Location:21 → 126
      CBM39; Carbohydrate binding domain (family 32)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NHB0.2 Q9NHB0

    Gene LinkOut

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