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    Rgl Ral guanine nucleotide dissociation stimulator-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44115, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Rglprovided by FlyBase
    Official Full Name
    Ral guanine nucleotide dissociation stimulator-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026376
    Locus tag
    Dmel_CG8865
    See related
    AllianceGenome:FB:FBgn0026376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8865; Dmel\CG8865; dRGL; DRgl; RalGDS; RasGDS; rgl
    Summary
    Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in positive regulation of epidermal growth factor receptor signaling pathway and positive regulation of stem cell proliferation. Predicted to be active in plasma membrane. Is expressed in organism. Orthologous to several human genes including RGL1 (ral guanine nucleotide dissociation stimulator like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rgl in Genome Data Viewer
    Location:
    70C5-70C5; 3-41 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13906897..13925335, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13899997..13918435, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene dyschronic Neighboring gene uncharacterized protein Neighboring gene Dynactin 1, p150 subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative trait loci for aggressive behavior in Drosophila melanogaster. Edwards AC, et al. Genetics, 2009 Jul. PMID 19414563, Free PMC Article
    2. The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation. Carmena A, et al. J Cell Biol, 2011 Nov 14. PMID 22084305, Free PMC Article
    3. Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi. van Dam TJ, et al. Cell Signal, 2009 Nov. PMID 19567266
    4. Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Proc Natl Acad Sci U S A, 2022 May 31. PMID 35617426, Free PMC Article
    5. Differential efficacy of genetically swapping GAL4. Chen YJ, et al. J Neurogenet, 2019 Mar-Jun. PMID 30939963

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Ras protein signal transduction IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ral guanine nucleotide dissociation stimulator-like
    Names
    CG8865-PA
    CG8865-PB
    CG8865-PC
    CG8865-PD
    CG8865-PE
    Ral guanine nucleotide dissociation stimulator-like ortholog
    Ral guanine nucleotide exchange factor
    Ral guanine nucleotide exchange factor 2
    Rgl-PA
    Rgl-PB
    Rgl-PC
    Rgl-PD
    Rgl-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13906897..13925335 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176327.2 → NP_788505.1  Ral guanine nucleotide dissociation stimulator-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788505.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BI2, Q9GR11
      Related
      FBpp0075537
      Conserved Domains (3) summary
      cd06224
      Location:66 → 198
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      cd00153
      Location:678 → 766
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:274 → 539
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    2. NM_176325.2 → NP_788503.1  Ral guanine nucleotide dissociation stimulator-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788503.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BI2, Q9GR11
      Related
      FBpp0075536
      Conserved Domains (3) summary
      cd06224
      Location:66 → 198
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      cd00153
      Location:678 → 766
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:274 → 539
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    3. NM_176326.2 → NP_788504.1  Ral guanine nucleotide dissociation stimulator-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788504.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BI2, Q9GR11
      Related
      FBpp0075538
      Conserved Domains (3) summary
      cd06224
      Location:66 → 198
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      cd00153
      Location:678 → 766
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:274 → 539
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    4. NM_079958.3 → NP_524697.1  Ral guanine nucleotide dissociation stimulator-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524697.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GR11, Q9U4U5, Q9VU99
      Related
      FBpp0075535
      Conserved Domains (3) summary
      cd06224
      Location:246 → 378
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      cd00153
      Location:858 → 946
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:454 → 719
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    5. NM_001274885.1 → NP_001261814.1  Ral guanine nucleotide dissociation stimulator-like, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261814.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCE9
      Conserved Domains (3) summary
      cd06224
      Location:246 → 378
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      cd00153
      Location:858 → 946
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:454 → 719
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCE9 M9PCE9
    Q86BI2 Q86BI2
    Q9GR11 Q9GR11
    Q9U4U5 Q9U4U5

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