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    CG7457 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38865, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7457provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035812
    Locus tag
    Dmel_CG7457
    See related
    AllianceGenome:FB:FBgn0035812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT13960; Dmel\CG7457
    Summary
    Predicted to enable histone binding activity. Predicted to be involved in double-strand break repair via homologous recombination and replication fork processing. Predicted to be active in nuclear replication fork. Is expressed in several structures, including antennal primordium; central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; and head epidermis primordium. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Sponastrime type. Orthologous to human TONSL (tonsoku like, DNA repair protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7457 in Genome Data Viewer
    Location:
    66A10-66A11; 3-21 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7719899..7726473, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7714905..7719573, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Peptidoglycan recognition protein SD Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ankyrin 2 Neighboring gene Medium-chain acyl-CoA dehydrogenase Neighboring gene uncharacterized protein Neighboring gene Sensory neuron membrane protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Host adaptation to viruses relies on few genes with different cross-resistance properties. Martins NE, et al. Proc Natl Acad Sci U S A, 2014 Apr 22. PMID 24711428, Free PMC Article
    2. Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster. Chen J, et al. Genome Res, 2008 Jan. PMID 18042644, Free PMC Article
    3. p53 directs focused genomic responses in Drosophila. Akdemir F, et al. Oncogene, 2007 Aug 9. PMID 17310982
    4. In vivo analysis of proteomes and interactomes using Parallel Affinity Capture (iPAC) coupled to mass spectrometry. Rees JS, et al. Mol Cell Proteomics, 2011 Jun. PMID 21447707, Free PMC Article
    5. Protein interaction mapping: a Drosophila case study. Formstecher E, et al. Genome Res, 2005 Mar. PMID 15710747, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear replication fork ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7457-PA
    CG7457-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7719899..7726473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316447.1 → NP_001303376.1  uncharacterized protein Dmel_CG7457, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MT49, Q9VSA4
      UniProtKB/TrEMBL
      T2GGE0
      Conserved Domains (8) summary
      COG0457
      Location:68 → 387
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      cd00116
      Location:1063 → 1360
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00204
      Location:535 → 647
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00034
      Location:1088 → 1115
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00006
      Location:163 → 191
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:543 → 639
      Ank_2; Ankyrin repeats (3 copies)
      pfam13424
      Location:21 → 95
      TPR_12; Tetratricopeptide repeat
      sd00045
      Location:539 → 569
      ANK; ANK repeat [structural motif]

    2. NM_139893.4 → NP_648150.1  uncharacterized protein Dmel_CG7457, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648150.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MT49, Q9VSA4
      UniProtKB/TrEMBL
      T2GGE0
      Related
      FBpp0076526
      Conserved Domains (8) summary
      COG0457
      Location:68 → 387
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      cd00116
      Location:1063 → 1360
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd00204
      Location:535 → 647
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00034
      Location:1088 → 1115
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00006
      Location:163 → 191
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:543 → 639
      Ank_2; Ankyrin repeats (3 copies)
      pfam13424
      Location:21 → 95
      TPR_12; Tetratricopeptide repeat
      sd00045
      Location:539 → 569
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSA4.1 Q9VSA4
    T2GGE0 T2GGE0

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