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    Uba4 Ubiquitin-like activating enzyme 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34187, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uba4provided by FlyBase
    Official Full Name
    Ubiquitin-like activating enzyme 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0032054
    Locus tag
    Dmel_CG13090
    See related
    AllianceGenome:FB:FBgn0032054
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13090; Dmel\CG13090; dMoaD; Mocs3
    Summary
    Predicted to enable URM1 activating enzyme activity; nucleotidyltransferase activity; and sulfurtransferase activity. Involved in molybdopterin cofactor biosynthetic process and protein urmylation. Located in cytoplasm. Orthologous to human MOCS3 (molybdenum cofactor synthesis 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Uba4 in Genome Data Viewer
    Location:
    29D4-29D4; 2-33 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8517411..8519176)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8517411..8519176)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class U Neighboring gene mitochondrial ribosomal protein L51 Neighboring gene Sgroppino Neighboring gene Angiotensin-converting enzyme-related Neighboring gene lemming B Neighboring gene lemming A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Urm1: an essential regulator of JNK signaling and oxidative stress in Drosophila melanogaster. Khoshnood B, et al. Cell Mol Life Sci, 2016 May. PMID 26715182, Free PMC Article
    2. A metazoan ATAC acetyltransferase subunit that regulates mitogen-activated protein kinase signaling is related to an ancient molybdopterin synthase component. Suganuma T, et al. Mol Cell Proteomics, 2012 May. PMID 22345504, Free PMC Article
    3. The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia. Otto N, et al. Nat Commun, 2018 Aug 29. PMID 30158546, Free PMC Article
    4. Uba1 functions in Atg7- and Atg3-independent autophagy. Chang TK, et al. Nat Cell Biol, 2013 Sep. PMID 23873149, Free PMC Article
    5. An Interaction Network of RNA-Binding Proteins Involved in Drosophila Oogenesis. Bansal P, et al. Mol Cell Proteomics, 2020 Sep. PMID 32554711, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables URM1 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdopterin-synthase sulfurtransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleotidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfurtransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiosulfate sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in molybdopterin cofactor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein urmylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein urmylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA thio-modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA wobble position uridine thiolation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble position uridine thiolation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of molybdopterin adenylyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin-like activating enzyme 4
    Names
    CG13090-PA
    CG13090-PB
    CG13090-PC
    Uba4 homologue
    Uba4 ortholog
    Uba4-PA
    Uba4-PB
    Uba4-PC
    ubiquitin activating enzyme 4
    NP_001260255.1
    NP_001260256.1
    NP_609240.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8517411..8519176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273327.1 → NP_001260256.1  Ubiquitin-like activating enzyme 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260256.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T486, Q9VLJ8
      UniProtKB/TrEMBL
      M9PCK7
      Conserved Domains (3) summary
      PRK07878
      Location:56 → 453
      PRK07878; molybdopterin biosynthesis-like protein MoeZ; Validated
      cd00757
      Location:71 → 299
      ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
      cd01526
      Location:336 → 453
      RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...

    2. NM_135396.3 → NP_609240.2  Ubiquitin-like activating enzyme 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609240.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T486, Q9VLJ8
      UniProtKB/TrEMBL
      M9PCK7
      Related
      FBpp0079295
      Conserved Domains (3) summary
      PRK07878
      Location:56 → 453
      PRK07878; molybdopterin biosynthesis-like protein MoeZ; Validated
      cd00757
      Location:71 → 299
      ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
      cd01526
      Location:336 → 453
      RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...

    3. NM_001273326.1 → NP_001260255.1  Ubiquitin-like activating enzyme 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260255.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T486, Q9VLJ8
      UniProtKB/TrEMBL
      M9PCK7
      Conserved Domains (3) summary
      PRK07878
      Location:56 → 453
      PRK07878; molybdopterin biosynthesis-like protein MoeZ; Validated
      cd00757
      Location:71 → 299
      ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
      cd01526
      Location:336 → 453
      RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCK7 M9PCK7
    Q9VLJ8.1 Q9VLJ8

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