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    CG4267 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33405, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4267provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264979
    Locus tag
    Dmel_CG4267
    See related
    AllianceGenome:FB:FBgn0264979
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31686; Dmel\CG4267; Dmel_CG4267
    Old locus tag
    Dmel_CG31686
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Is expressed in embryonic large intestine and organism. Orthologous to human PLA1A (phospholipase A1 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4267 in Genome Data Viewer
    Location:
    22D5-22D5; 2-5 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2242378..2245274)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2242378..2245274)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Testis EndoG-Like 2 Neighboring gene Testis EndoG-Like 1 Neighboring gene long non-coding RNA:CR42859 Neighboring gene Serine protease 12 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster. Lawniczak MK, et al. Mol Biol Evol, 2007 Sep. PMID 17573377
    2. Multiple Quantitative Trait Loci Influence the Shape of a Male-Specific Genital Structure in Drosophila melanogaster. McNeil CL, et al. G3 (Bethesda), 2011 Oct. PMID 22384345, Free PMC Article
    3. How the insect immune system interacts with an obligate symbiotic bacterium. Douglas AE, et al. Proc Biol Sci, 2011 Feb 7. PMID 20719775, Free PMC Article
    4. Age-dependent changes in the transcription profile of long-lived Drosophila over-expressing glutamate cysteine ligase. Radyuk SN, et al. Mech Ageing Dev, 2012 Jun. PMID 22579812
    5. The Toll pathway underlies host sexual dimorphism in resistance to both Gram-negative and Gram-positive bacteria in mated Drosophila. Duneau DF, et al. BMC Biol, 2017 Dec 21. PMID 29268741, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4267-PA
    CG4267-PB
    NP_001259919.1
    NP_608661.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2242378..2245274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272990.1 → NP_001259919.1  uncharacterized protein Dmel_CG4267, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259919.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ96
      Conserved Domains (2) summary
      cd00707
      Location:71 → 347
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      pfam00151
      Location:64 → 351
      Lipase; Lipase

    2. NM_134817.3 → NP_608661.1  uncharacterized protein Dmel_CG4267, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608661.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ96
      Related
      FBpp0077431
      Conserved Domains (2) summary
      cd00707
      Location:71 → 347
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      pfam00151
      Location:64 → 351
      Lipase; Lipase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQ96 Q9VQ96

    Gene LinkOut

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