U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Fam149b family with sequence similarity 149, member B [ Mus musculus (house mouse) ]

    Gene ID: 105428, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fam149bprovided by MGI
    Official Full Name
    family with sequence similarity 149, member Bprovided by MGI
    Primary source
    MGI:MGI:2145567
    See related
    Ensembl:ENSMUSG00000039599 AllianceGenome:MGI:2145567
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam149b1; mKIAA0974
    Summary
    Predicted to be involved in cilium assembly and protein localization to cilium. Predicted to be located in cilium. Human ortholog(s) of this gene implicated in Joubert syndrome. Orthologous to human FAM149B1 (family with sequence similarity 149 member B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 11.2), CNS E14 (RPKM 7.7) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fam149b in Genome Data Viewer
    Location:
    14 A3; 14 11.52 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20398221..20433559)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20348158..20383491)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1470 Neighboring gene nudix hydrolase 13 Neighboring gene ecdysoneless cell cycle regulator Neighboring gene STARR-seq mESC enhancer starr_36108 Neighboring gene STARR-positive B cell enhancer ABC_E7295 Neighboring gene predicted gene, 30054 Neighboring gene STARR-positive B cell enhancer ABC_E7296 Neighboring gene STARR-positive B cell enhancer ABC_E11564 Neighboring gene STARR-positive B cell enhancer ABC_E3105 Neighboring gene DnaJ heat shock protein family (Hsp40) member C9 Neighboring gene mitochondrial ribosomal protein S16

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Clone Names

    • MGC32264

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cilium assembly  
    involved_in cilium assembly  
    involved_in cilium assembly  
    involved_in protein localization to cilium  
    involved_in protein localization to cilium  
    involved_in protein localization to cilium  
    Component Evidence Code Pubs
    located_in cilium  

    General protein information

    Preferred Names
    primary cilium assembly protein FAM149B1
    Names
    protein FAM149B1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024512.3NP_001019683.1  primary cilium assembly protein FAM149B1 isoform 1

      See identical proteins and their annotated locations for NP_001019683.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC121801
      Consensus CDS
      CCDS49409.1
      UniProtKB/Swiss-Prot
      A0JLS8, Q6NSV7, Q6PES0, Q6ZQ13, Q8CCW6, Q8R3J2
      Related
      ENSMUSP00000087985.6, ENSMUST00000090499.13
      Conserved Domains (1) summary
      pfam12516
      Location:117181
      DUF3719; Protein of unknown function (DUF3719)
    2. NM_001177633.2NP_001171104.1  primary cilium assembly protein FAM149B1 isoform 3

      See identical proteins and their annotated locations for NP_001171104.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks multiple 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (3) is shorter and has a different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC121801
      Consensus CDS
      CCDS49408.1
      UniProtKB/Swiss-Prot
      Q6NSV7
      Related
      ENSMUSP00000153509.2, ENSMUST00000224721.2
      Conserved Domains (1) summary
      pfam12516
      Location:117181
      DUF3719; Protein of unknown function (DUF3719)
    3. NM_001360364.2NP_001347293.1  primary cilium assembly protein FAM149B1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121801
      Conserved Domains (1) summary
      pfam12516
      Location:117181
      DUF3719; Protein of unknown function (DUF3719)
    4. NM_001360365.2NP_001347294.1  primary cilium assembly protein FAM149B1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC121801
      Conserved Domains (1) summary
      pfam12516
      Location:64100
      DUF3719; Protein of unknown function (DUF3719)
    5. NM_001425986.1NP_001412915.1  primary cilium assembly protein FAM149B1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC121801
    6. NM_001425987.1NP_001412916.1  primary cilium assembly protein FAM149B1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC121801
    7. NM_001425988.1NP_001412917.1  primary cilium assembly protein FAM149B1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC121801
      Related
      ENSMUSP00000056907.7, ENSMUST00000051915.7
    8. NM_001425989.1NP_001412918.1  primary cilium assembly protein FAM149B1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC121801
    9. NM_001425990.1NP_001412919.1  primary cilium assembly protein FAM149B1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC121801
    10. NM_001425991.1NP_001412920.1  primary cilium assembly protein FAM149B1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC121801
      UniProtKB/TrEMBL
      A0A2C9F2B4
    11. NM_001425992.1NP_001412921.1  primary cilium assembly protein FAM149B1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC121801
      UniProtKB/TrEMBL
      A0A2C9F2B4
      Related
      ENSMUSP00000045247.7, ENSMUST00000037698.13
    12. NM_172379.4NP_759011.2  primary cilium assembly protein FAM149B1 isoform 2

      See identical proteins and their annotated locations for NP_759011.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC121801
      Consensus CDS
      CCDS49410.1
      UniProtKB/Swiss-Prot
      Q6NSV7
      Related
      ENSMUSP00000087989.5, ENSMUST00000090503.12
      Conserved Domains (1) summary
      pfam12516
      Location:117169
      DUF3719; Protein of unknown function (DUF3719)

    RNA

    1. NR_189649.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121801
    2. NR_189650.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121801
    3. NR_189651.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121801

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      20398221..20433559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158339.1XP_036014232.1  primary cilium assembly protein FAM149B1 isoform X1

      Conserved Domains (1) summary
      pfam12516
      Location:117181
      DUF3719; Protein of unknown function (DUF3719)
    2. XM_036158343.1XP_036014236.1  primary cilium assembly protein FAM149B1 isoform X6

      Conserved Domains (1) summary
      pfam12516
      Location:117181
      DUF3719; Protein of unknown function (DUF3719)
    3. XM_036158342.1XP_036014235.1  primary cilium assembly protein FAM149B1 isoform X4

      Conserved Domains (1) summary
      pfam12516
      Location:117181
      DUF3719; Protein of unknown function (DUF3719)
    4. XM_036158345.1XP_036014238.1  primary cilium assembly protein FAM149B1 isoform X8

      Conserved Domains (1) summary
      pfam12516
      Location:117169
      DUF3719; Protein of unknown function (DUF3719)
    5. XM_036158344.1XP_036014237.1  primary cilium assembly protein FAM149B1 isoform X7

      Conserved Domains (1) summary
      pfam12516
      Location:64100
      DUF3719; Protein of unknown function (DUF3719)
    6. XM_036158349.1XP_036014242.1  primary cilium assembly protein FAM149B1 isoform X12

    7. XM_036158353.1XP_036014246.1  primary cilium assembly protein FAM149B1 isoform X16

    8. XM_036158340.1XP_036014233.1  primary cilium assembly protein FAM149B1 isoform X2

      Conserved Domains (1) summary
      pfam12516
      Location:83147
      DUF3719; Protein of unknown function (DUF3719)
    9. XM_036158346.1XP_036014239.1  primary cilium assembly protein FAM149B1 isoform X9

      Conserved Domains (1) summary
      pfam12516
      Location:973
      DUF3719; Protein of unknown function (DUF3719)
    10. XM_036158341.1XP_036014234.1  primary cilium assembly protein FAM149B1 isoform X3

      Conserved Domains (1) summary
      pfam12516
      Location:117181
      DUF3719; Protein of unknown function (DUF3719)
    11. XM_036158351.1XP_036014244.1  primary cilium assembly protein FAM149B1 isoform X13

      Conserved Domains (1) summary
      pfam12516
      Location:117181
      DUF3719; Protein of unknown function (DUF3719)
    12. XM_011244880.2XP_011243182.1  primary cilium assembly protein FAM149B1 isoform X17

      Conserved Domains (1) summary
      pfam12516
      Location:117181
      DUF3719; Protein of unknown function (DUF3719)
    13. XM_006518336.1XP_006518399.1  primary cilium assembly protein FAM149B1 isoform X15

      See identical proteins and their annotated locations for XP_006518399.1

    14. XM_036158352.1XP_036014245.1  primary cilium assembly protein FAM149B1 isoform X14

    RNA

    1. XR_004938355.1 RNA Sequence

    2. XR_004938356.1 RNA Sequence

    3. XR_001781076.2 RNA Sequence

    4. XR_004938354.1 RNA Sequence

    5. XR_004938353.1 RNA Sequence

    6. XR_001781072.2 RNA Sequence

      Related
      ENSMUST00000225834.2
    7. XR_004938357.1 RNA Sequence

    8. XR_004938358.1 RNA Sequence

    External link. Please review our privacy policy.