Kap3 Kinesin associated protein 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Kap3provided by FlyBase
Official Full Name: Kinesin associated protein 3provided by FlyBase
Primary source: FLYBASE:FBgn0028421
Locus tag: Dmel_CG11759
See related: AllianceGenome:FB:FBgn0028421
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11759; dKAP3; Dmel\CG11759; DmKap; DmKAP; Kap; KAP; kap3; KAP3
Summary: Predicted to enable kinesin binding activity. Involved in several processes, including establishment or maintenance of microtubule cytoskeleton polarity; non-motile cilium assembly; and positive regulation of canonical Wnt signaling pathway. Predicted to be part of kinesin II complex. Predicted to be active in axoneme and ciliary transition zone. Is expressed in several structures, including embryonic/larval optic lobe; embryonic/larval optic stalk; ganglia; germline cell; and sense organ. Orthologous to human KIFAP3 (kinesin associated protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 10B3-10B3; 1-34 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (11334187..11340084, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (11228220..11234117, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kinesin associated protein, DmKAP, binding harnesses the C-terminal ends of the Drosophila kinesin-2 stalk heterodimer.
Title: Kinesin associated protein, DmKAP, binding harnesses the C-terminal ends of the Drosophila kinesin-2 stalk heterodimer.
Observations suggest that KAP stabilizes the motor subunit heterodimer and help assemble a greater kinesin-2 complex in vivo.
Title: KAP, the accessory subunit of kinesin-2, binds the predicted coiled-coil stalk of the motor subunits.
KAP plays an essential role in Kinesin II function, which is required for the axoneme growth and maintenance of the cilia in Drosophila type I sensory neurons.
Title: Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails.
Data suggest that Kap participates in the transport of signalling components required for instructive interactions between germline and soma cells.
Title: Follicle separation during Drosophila oogenesis requires the activity of the kinesin II-associated polypeptide Kap in germline cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables kinesin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of microtubule cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in sperm axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
is_active_in ciliary transition zone	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinesin associated protein 3

Names: CG11759-PF; CG11759-PG; CG11759-PH; CG11759-PM; CG11759-PN; Kap3-PF; Kap3-PG; Kap3-PH; Kap3-PM; Kap3-PN; Kinesin-2; Kinesin-associated protein 3; kinesin II accessory protein; kinesin accessory protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

11334187..11340084 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001103480.2 → NP_001096950.2 kinesin associated protein 3, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096950.2

Status: REVIEWED

UniProtKB/TrEMBL

A8JUR4

Conserved Domains (2) summary

cd00020
Location:438 → 539

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam05804
Location:14 → 864

KAP; Kinesin-associated protein (KAP)
NM_001103481.3 → NP_001096951.3 kinesin associated protein 3, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001096951.3

Status: REVIEWED

UniProtKB/TrEMBL

A8JUR5

Conserved Domains (2) summary

cd00020
Location:530 → 631

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam05804
Location:107 → 956

KAP; Kinesin-associated protein (KAP)
NM_001272516.2 → NP_001259445.2 kinesin associated protein 3, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259445.2

Status: REVIEWED

UniProtKB/TrEMBL

M9PGW1

Conserved Domains (2) summary

cd00020
Location:531 → 632

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam05804
Location:107 → 957

KAP; Kinesin-associated protein (KAP)
NM_167278.3 → NP_727512.3 kinesin associated protein 3, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727512.3

Status: REVIEWED

UniProtKB/TrEMBL

Q7YU04, Q9VZ07

Conserved Domains (2) summary

cd00020
Location:531 → 632

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam05804
Location:107 → 957

KAP; Kinesin-associated protein (KAP)
NM_001144714.1 → NP_001138186.1 kinesin associated protein 3, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138186.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z139

Conserved Domains (2) summary

cd00020
Location:438 → 539

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam05804
Location:14 → 864

KAP; Kinesin-associated protein (KAP)