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    Cse1 Chromosome segregation 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35016, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cse1provided by FlyBase
    Official Full Name
    Chromosome segregation 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0022213
    Locus tag
    Dmel_CG13281
    See related
    AllianceGenome:FB:FBgn0022213
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD14270; cas; Cas; CAS; CG13281; cse; dcas; Dcas; Dmel\CG13281; l(2)k03902
    Summary
    Predicted to enable nuclear export signal receptor activity. Involved in protein export from nucleus. Located in cytosol; nuclear envelope; and nucleoplasm. Is expressed in adult brain cell body rind and adult head. Orthologous to human CSE1L (chromosome segregation 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cse1 in Genome Data Viewer
    Location:
    36B1-36B2; 2-53 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16821156..16825207, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16821156..16825207, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase family 37 member D1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene midway Neighboring gene Aspartyl-tRNA synthetase, mitochondrial Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the midway gene disrupt a Drosophila acyl coenzyme A: diacylglycerol acyltransferase. Buszczak M, et al. Genetics, 2002 Apr. PMID 11973306, Free PMC Article
    2. Biological significance of the importin-β family-dependent nucleocytoplasmic transport pathways. Kimura M, et al. Traffic, 2014 Jul. PMID 24766099
    3. Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster. Lichtneckert R, et al. Development, 2007 Apr. PMID 17314131
    4. Age-dependent expression profiles of two adaptogenic systems and thermotolerance in Drosophila melanogaster. Shilova V, et al. Cell Stress Chaperones, 2020 Mar. PMID 32040825, Free PMC Article
    5. Ran is required before metaphase for spindle assembly and chromosome alignment and after metaphase for chromosome segregation and spindle midbody organization. Silverman-Gavrila RV, et al. Mol Biol Cell, 2006 Apr. PMID 16481399, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. an important role for Cas proteins in cell-cell adhesion signaling in development
      Title: Dcas supports cell polarization and cell-cell adhesion complexes in development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope HDA PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm HDA PubMed 

    General protein information

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    Preferred Names
    chromosome segregation 1
    Names
    CAS
    CAS/CSE1 segregation protein
    CG13281-PA
    Cse1-PA
    Importin-alpha re-exporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16821156..16825207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078864.3 → NP_523588.2  chromosome segregation 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523588.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9UB14, Q9VJH4, Q9XZU1
      Related
      FBpp0080484
      Conserved Domains (3) summary
      pfam03378
      Location:530 → 966
      CAS_CSE1; CAS/CSE protein, C-terminus
      pfam03810
      Location:29 → 105
      IBN_N; Importin-beta N-terminal domain
      pfam08506
      Location:159 → 528
      Cse1; Cse1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XZU1.2 Q9XZU1

    Gene LinkOut

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