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    scu scully [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32789, updated on 27-Dec-2024

    Summary

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    Official Symbol
    scuprovided by FlyBase
    Official Full Name
    scullyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0021765
    Locus tag
    Dmel_CG7113
    See related
    AllianceGenome:FB:FBgn0021765
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    17beta-HSD10; CG7113; Dmel\CG7113; HL-X; HLII; HSD17B10; l(1)16Fd; l(1)17Ad; MRPP2; Scu
    Summary
    Enables acetoacetyl-CoA reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in several processes, including acyl-CoA metabolic process; mitochondrial tRNA processing; and steroid metabolic process. Located in mitochondrion. Part of mitochondrial ribonuclease P complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval salivary gland; germline cell; and gut section. Used to study syndromic X-linked intellectual disability type 10. Human ortholog(s) of this gene implicated in pheochromocytoma and syndromic X-linked intellectual disability type 10. Orthologous to human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See scu in Genome Data Viewer
    Location:
    16F6-16F6; 1-59 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18091259..18092853)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17985292..17986886)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene transcriptional Adaptor 3 Neighboring gene Swt1 RNA endoribonuclease Neighboring gene Rho GTPase activating protein at 16F Neighboring gene Multivesicular body subunit 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial RNA granule modulates manganese-dependent cell toxicity. Werner E, et al. Mol Biol Cell, 2022 Oct 1. PMID 35921164, Free PMC Article
    2. Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD. Shafqat N, et al. Biochem J, 2003 Nov 15. PMID 12917011, Free PMC Article
    3. A chemical genomics approach to drug reprofiling in oncology: Antipsychotic drug risperidone as a potential adenocarcinoma treatment. Dilly SJ, et al. Cancer Lett, 2017 May 1. PMID 28188816
    4. ERAB contains a putative noncleavable signal peptide. Sambamurti K, et al. Biochem Biophys Res Commun, 1998 Aug 19. PMID 9712734
    5. Reduction of Drosophila Mitochondrial RNase P in Skeletal and Heart Muscle Causes Muscle Degeneration, Cardiomyopathy, and Heart Arrhythmia. Saoji M, et al. Front Cell Dev Biol, 2022. PMID 35663400, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Risperidone inhibits drosophila 17-beta-HSD10 in chemical genomics screen.
      Title: A chemical genomics approach to drug reprofiling in oncology: Antipsychotic drug risperidone as a potential adenocarcinoma treatment.
    2. we have identified the three proteins composing Drosophila mt:RNase P: Mulder (PRORP), Scully (MRPP2) and Roswell (MRPP1). H. reducing levels of each causes mitochondrial deficits, which appear to be due at least in part to defective mitochondrial tRNA processing. Overexpressing two members of the complex, Mulder and Roswell, is also lethal, and in the case of Mulder, causes abnormal mitochondrial morphology
      Title: Loss of the mitochondrial protein-only ribonuclease P complex causes aberrant tRNA processing and lethality in Drosophila.
    3. Comparison of substrate specificity of human and Drosophila melanogaster type 10 17b-hydroxysteroid dehydrogenases
      Title: Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 7-beta-hydroxysteroid dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetoacetyl-CoA reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steroid dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables testosterone dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in androgen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in androgen metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ecdysone metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in estrogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in estrogen metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in steroid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    scully
    Names
    17-beta-hydroxysteroid dehydrogenase 10 ortholog
    3-hydroxyacyl-CoA dehydrogenase
    CG7113-PA
    CG7113-PB
    haplo-lethal region II
    lethal(1)17Ad
    scu-PA
    scu-PB
    NP_001245729.1
    NP_523396.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18091259..18092853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258800.2 → NP_001245729.1  scully, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245729.1

      Status: REVIEWED

      Conserved Domains (1) summary
      cl25409
      Location:1 → 126
      SDR; Short-chain dehydrogenases/reductases (SDR)

    2. NM_078672.5 → NP_523396.1  scully, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523396.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D5A7S2, G7H840, O18404, Q059C3, Q8MRC1
      Related
      FBpp0074285
      Conserved Domains (1) summary
      cd05371
      Location:3 → 255
      HSD10-like_SDR_c; 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D5A7S2 D5A7S2
    O18404.1 O18404

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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