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    lbm late bloomer [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35623, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lbmprovided by FlyBase
    Official Full Name
    late bloomerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016032
    Locus tag
    Dmel_CG2374
    See related
    AllianceGenome:FB:FBgn0016032
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2374; Dm.Tsp42Em; Dmel\CG2374; Ibm; lbl; Lbm; LBM
    Summary
    Involved in synapse assembly. Located in extracellular region. Is expressed in several structures, including central brain primordium; embryonic dorsal epidermis; ganglia; larval neurons; and sensory nervous system primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lbm in Genome Data Viewer
    Location:
    42E6-42E6; 2-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7049238..7051964)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2936743..2939469)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 42Ej Neighboring gene Tetraspanin 42Ek Neighboring gene Tetraspanin 42El Neighboring gene Tetraspanin 42En Neighboring gene Tetraspanin 42Ep Neighboring gene Tetraspanin 42Eo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A neural tetraspanin, encoded by late bloomer, that facilitates synapse formation. Kopczynski CC, et al. Science, 1996 Mar 29. PMID 8596956
    2. A putative vesicular transporter expressed in Drosophila mushroom bodies that mediates sexual behavior may define a neurotransmitter system. Brooks ES, et al. Neuron, 2011 Oct 20. PMID 22017990, Free PMC Article
    3. New neurons use 'lookouts' to navigate nervous system. Roush W. Science, 1996 Mar 29. PMID 8596946
    4. 'Identify' and 'lock in': molecular integration during synaptic target recognition. Hoang B, et al. Cell Mol Life Sci, 1999 Aug 30. PMID 10518989, Free PMC Article
    5. The Drosophila SH2-SH3 adapter protein Dock is expressed in embryonic axons and facilitates synapse formation by the RP3 motoneuron. Desai CJ, et al. Development, 1999 Apr. PMID 10068645

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In embryos lacking Lbm protein, motoneurons reach their muscle targets, but initially fail to form synaptic terminals. During larval stages, however, functional contacts are formed.
      Title: Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    late bloomer
    Names
    CG2374-PA
    CG2374-PB
    latebloomer
    lbm-PA
    lbm-PB
    tetraspanin 42E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7049238..7051964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273828.1 → NP_001260757.1  late bloomer, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260757.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24188, Q9V4H0
      UniProtKB/TrEMBL
      A0A0B4KF78
      Conserved Domains (2) summary
      cd03127
      Location:109 → 169
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:8 → 198
      Tetraspannin; Tetraspanin family

    2. NM_078915.3 → NP_523639.1  late bloomer, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523639.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24188, Q9V4H0
      UniProtKB/TrEMBL
      A0A0B4KF78
      Related
      FBpp0088104
      Conserved Domains (2) summary
      cd03127
      Location:109 → 169
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:8 → 198
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KF78 A0A0B4KF78
    Q24188.1 Q24188

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