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    nonA-l nonA-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42026, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nonA-lprovided by FlyBase
    Official Full Name
    nonA-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015520
    Locus tag
    Dmel_CG10328
    See related
    AllianceGenome:FB:FBgn0015520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD09360; CG10328; Dmel\CG10328; LD09360; nonA 1; nonA-1; NonA-like; PSF; Z
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in adult head. Human ortholog(s) of this gene implicated in cardiomyopathy; intellectual disability; and syndromic X-linked intellectual disability 34. Orthologous to human NONO (non-POU domain containing octamer binding); PSPC1 (paraspeckle component 1); and SFPQ (splicing factor proline and glutamine rich). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nonA-l in Genome Data Viewer
    Location:
    89D6-89D6; 3-59 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16640205..16643112)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12465927..12468834)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Coiled-coil domain containing protein 114 Neighboring gene Fasciclin 1 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 Neighboring gene uncharacterized protein Neighboring gene Chaperonin containing TCP1 subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Emerging Role of the RNA-Binding Protein SFPQ in Neuronal Function and Neurodegeneration. Lim YW, et al. Int J Mol Sci, 2020 Sep 28. PMID 32998269, Free PMC Article
    2. The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold. Knott GJ, et al. Nucleic Acids Res, 2016 May 19. PMID 27084935, Free PMC Article
    3. Drosophila melanogaster P1 genomic clone DS05563 contains the chaperonin-encoding gene Cctg. Walkley NA, et al. Gene, 1996 Jun 1. PMID 8666276
    4. Mathematical model to predict regions of chromatin attachment to the nuclear matrix. Singh GB, et al. Nucleic Acids Res, 1997 Apr 1. PMID 9060438, Free PMC Article
    5. Vigilins bind to promiscuously A-to-I-edited RNAs and are involved in the formation of heterochromatin. Wang Q, et al. Curr Biol, 2005 Feb 22. PMID 15723802

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nonA-like
    Names
    CG10328-PA
    CG10328-PB
    no-on transient A gene
    no-on transient A-like
    nonA-l-PA
    nonA-l-PB
    predicted gene Z

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16640205..16643112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275717.1 → NP_001262646.1  nonA-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262646.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24113, Q7JPC7, Q9VES2
      Conserved Domains (5) summary
      cd12945
      Location:409 → 508
      NOPS_NONA_like; NOPS domain, including C-terminal coiled-coil region, in p54nrb/PSF/PSP1 homologs from invertebrate species
      cd12332
      Location:264 → 334
      RRM1_p54nrb_like; RNA recognition motif 1 in the p54nrb/PSF/PSP1 family
      cd12333
      Location:339 → 418
      RRM2_p54nrb_like; RNA recognition motif 2 in the p54nrb/PSF/PSP1 family
      pfam03938
      Location:479 → 578
      OmpH; Outer membrane protein (OmpH-like)
      pfam14739
      Location:479 → 559
      DUF4472; Domain of unknown function (DUF4472)

    2. NM_080492.3 → NP_536740.1  nonA-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536740.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24113, Q7JPC7, Q9VES2
      Related
      FBpp0082785
      Conserved Domains (5) summary
      cd12945
      Location:409 → 508
      NOPS_NONA_like; NOPS domain, including C-terminal coiled-coil region, in p54nrb/PSF/PSP1 homologs from invertebrate species
      cd12332
      Location:264 → 334
      RRM1_p54nrb_like; RNA recognition motif 1 in the p54nrb/PSF/PSP1 family
      cd12333
      Location:339 → 418
      RRM2_p54nrb_like; RNA recognition motif 2 in the p54nrb/PSF/PSP1 family
      pfam03938
      Location:479 → 578
      OmpH; Outer membrane protein (OmpH-like)
      pfam14739
      Location:479 → 559
      DUF4472; Domain of unknown function (DUF4472)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24113 Q24113
    Q7JPC7 Q7JPC7
    Q8MS20 Q8MS20

    Gene LinkOut

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