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    Dhc16F Dynein heavy chain at 16F [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32785, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhc16Fprovided by FlyBase
    Official Full Name
    Dynein heavy chain at 16Fprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283476
    Locus tag
    Dmel_CG7092
    See related
    AllianceGenome:FB:FBgn0283476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atoll; CG7092; cvl-6; dhc; Dhc; DHC; DHC9; Dmel\CG7092
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in flagellated sperm motility. Is active in sperm flagellum. Is expressed in chordotonal neurons; spermatogonium; spermatozoon; and testis. Orthologous to human DNAH6 (dynein axonemal heavy chain 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dhc16F in Genome Data Viewer
    Location:
    16F6-16F6; 1-59 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18064483..18078472)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17958516..17972505)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Shaker Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transcriptional Adaptor 3 Neighboring gene Swt1 RNA endoribonuclease

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. WING VEIN DEVELOPMENT IN CROSSVEINLESS-LIKE STRAINS OF DROSOPHILA MELANOGASTER. MOHLER JD, et al. Genetics, 1964 Dec. PMID 14239796, Free PMC Article
    2. PRELIMINARY GENETIC ANALYSIS OF CROSSVEINLESS-LIKE STRAINS OF DROSOPHILA MELANOGASTER. MOHLER JD. Genetics, 1965 Apr. PMID 14330700, Free PMC Article
    3. A family of dynein genes in Drosophila melanogaster. Rasmusson K, et al. Mol Biol Cell, 1994 Jan. PMID 8186464, Free PMC Article
    4. The Y chromosomal fertility factor Threads in Drosophila hydei harbors a functional gene encoding an axonemal dynein beta heavy chain protein. Kurek R, et al. Genetics, 1998 Jul. PMID 9649526, Free PMC Article
    5. A force balance model of early spindle pole separation in Drosophila embryos. Cytrynbaum EN, et al. Biophys J, 2003 Feb. PMID 12547760, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein heavy chain at 16F
    Names
    CG7092-PA
    Dhc16F-PA
    crossveinless-like 6
    dynein-related heavy chain polypeptide

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18064483..18078472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078670.3 → NP_523394.1  dynein heavy chain at 16F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523394.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWZ3
      Related
      FBpp0074283
      Conserved Domains (5) summary
      pfam03028
      Location:3342 → 4066
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:829 → 1234
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2625 → 2957
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:2985 → 3201
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1373 → 1603
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MS83 Q8MS83
    Q9VWZ3 Q9VWZ3
    V9GZL8 V9GZL8

    Gene LinkOut

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