U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ak3 Adenylate kinase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41318, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ak3provided by FlyBase
    Official Full Name
    Adenylate kinase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0042094
    Locus tag
    Dmel_CG6612
    See related
    AllianceGenome:FB:FBgn0042094
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Adk3; AK3; bs12h03.y1; CG6612; Dak3; DAK3; Dmel\CG6612
    Summary
    Enables adenylate kinase activity. Predicted to be involved in ADP biosynthetic process; AMP metabolic process; and nucleoside triphosphate biosynthetic process. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Orthologous to several human genes including AK3 (adenylate kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ak3 in Genome Data Viewer
    Location:
    86C7-86C7; 3-50 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10887345..10889588, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6713067..6715310, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Thiamine pyrophosphate carrier protein 1 Neighboring gene uncharacterized protein Neighboring gene leash Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45577

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. cDNA cloning and chromosomal mapping of the gene encoding adenylate kinase 2 from Drosophila melanogaster. Noma T, et al. Biochim Biophys Acta, 2000 Jan 31. PMID 10786623
    2. Adenylate kinase isozyme 2 is essential for growth and development of Drosophila melanogaster. Fujisawa K, et al. Comp Biochem Physiol B Biochem Mol Biol, 2009 May. PMID 19416704
    3. FOXO-regulated transcription restricts overgrowth of Tsc mutant organs. Harvey KF, et al. J Cell Biol, 2008 Feb 25. PMID 18299344, Free PMC Article
    4. Elevation of glutamine level by selenophosphate synthetase 1 knockdown induces megamitochondrial formation in Drosophila cells. Shim MS, et al. J Biol Chem, 2009 Nov 20. PMID 19755423, Free PMC Article
    5. Identical longevity phenotypes are characterized by different patterns of gene expression and oxidative damage. Arking R, et al. Exp Gerontol, 2000 May. PMID 10832056

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside triphosphate adenylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ADP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in AMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside triphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    adenylate kinase 3
    Names
    ADENYLATE KINASE - 3
    Ak3-PA
    Ak3-PB
    Ak3-PC
    Ak3-PD
    CG6612-PA
    CG6612-PB
    CG6612-PC
    CG6612-PD
    adenylate kinase-3
    NP_001287279.1
    NP_001287280.1
    NP_524312.1
    NP_731529.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10887345..10889588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300350.1 → NP_001287279.1  adenylate kinase 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287279.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGU6
      Conserved Domains (2) summary
      cd01428
      Location:7 → 201
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:7 → 211
      adk; adenylate kinase

    2. NM_001300351.1 → NP_001287280.1  adenylate kinase 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287280.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGU6
      Conserved Domains (2) summary
      cd01428
      Location:7 → 201
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:7 → 211
      adk; adenylate kinase

    3. NM_079588.3 → NP_524312.1  adenylate kinase 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524312.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGU6
      Related
      FBpp0081807
      Conserved Domains (2) summary
      cd01428
      Location:7 → 201
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:7 → 211
      adk; adenylate kinase

    4. NM_169373.2 → NP_731529.1  adenylate kinase 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731529.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGU6
      Related
      FBpp0081806
      Conserved Domains (2) summary
      cd01428
      Location:7 → 201
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01351
      Location:7 → 211
      adk; adenylate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGU6 Q9VGU6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous