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    CG9389 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40347, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG9389provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037064
    Locus tag
    Dmel_CG9389
    See related
    AllianceGenome:FB:FBgn0037064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    142336_at; Dmel\CG9389; IMP
    Summary
    Predicted to enable inositol monophosphate 1-phosphatase activity. Predicted to be involved in inositol metabolic process and signal transduction. Predicted to be located in cytoplasm. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in bipolar disorder and schizophrenia. Orthologous to human IMPA2 (inositol monophosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9389 in Genome Data Viewer
    Location:
    78C3-78C3; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21268392..21270580, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21261492..21263680, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ecdysone-induced protein 78C Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45162 Neighboring gene uncharacterized protein Neighboring gene Acetyl Coenzyme A synthase Neighboring gene pumpless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. Lemos B, et al. Science, 2008 Jan 4. PMID 18174442
    2. A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux. Allen EA, et al. J Cell Biol, 2020 Nov 2. PMID 32915229, Free PMC Article
    3. Genome-wide analysis on inbreeding effects on gene expression in Drosophila melanogaster. Kristensen TN, et al. Genetics, 2005 Sep. PMID 15944359, Free PMC Article
    4. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article
    5. Quantitative proteomics and phosphoproteomics reveal insights into mechanisms of ocnus function in Drosophila testis development. Zheng Y, et al. BMC Genomics, 2023 May 26. PMID 37237333, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables inositol monophosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol monophosphate 1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol monophosphate 1-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9389-PA
    NP_649295.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21268392..21270580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141038.3 → NP_649295.1  uncharacterized protein Dmel_CG9389 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649295.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP62
      Related
      FBpp0078069
      Conserved Domains (1) summary
      cd01639
      Location:279 → 526
      IMPase; IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VP62 Q9VP62

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