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    Atxn7 Ataxin 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33423, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Atxn7provided by FlyBase
    Official Full Name
    Ataxin 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0031420
    Locus tag
    Dmel_CG9866
    See related
    AllianceGenome:FB:FBgn0031420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ataxin-7; Ataxin7; CG9866; dATXN7; Dmel\CG9866
    Summary
    Involved in SAGA complex assembly. Located in nucleus and polytene chromosome. Part of SAGA complex. Is expressed in several structures, including dorsal pharyngeal muscle primordium; head mesoderm; larval muscle cell; larval muscle system; and somatic muscle primordium. Used to study neurodegenerative disease and spinocerebellar ataxia type 7. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Atxn7 in Genome Data Viewer
    Location:
    22E1-22E1; 2-6 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2375841..2380506)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2375841..2380506)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44982 Neighboring gene uncharacterized protein Neighboring gene EGF-domain O-GlcNAc transferase Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class W a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Progressive degeneration in a new Drosophila model of spinocerebellar ataxia type 7. Sujkowski A, et al. Sci Rep, 2024 Jun 21. PMID 38906973, Free PMC Article
    2. Drosophila models reveal novel insights into mechanisms underlying neurodegeneration. Mohan RD, et al. Fly (Austin), 2014. PMID 25483136, Free PMC Article
    3. Enzymatic modules of the SAGA chromatin-modifying complex play distinct roles in Drosophila gene expression and development. Li X, et al. Genes Dev, 2017 Aug 1. PMID 28887412, Free PMC Article
    4. Ataxin-7 and Non-stop coordinate SCAR protein levels, subcellular localization, and actin cytoskeleton organization. Cloud V, et al. Elife, 2019 Jul 26. PMID 31348003, Free PMC Article
    5. A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging. Erez N, et al. Elife, 2021 Feb 25. PMID 33629655, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in SAGA complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ataxin 7
    Names
    Ataxin-7
    Atxn7-PA
    Atxn7-PB
    Atxn7-PC
    Atxn7-PD
    CG9866-PA
    CG9866-PB
    CG9866-PC
    CG9866-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2375841..2380506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134833.5 → NP_608677.1  ataxin 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608677.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQB6
      Related
      FBpp0077445

    2. NM_001273004.1 → NP_001259933.1  ataxin 7, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259933.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQB6

    3. NM_164481.2 → NP_722803.1  ataxin 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722803.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQB6
      Related
      FBpp0077446

    4. NM_001273003.1 → NP_001259932.1  ataxin 7, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259932.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQB6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQB6 Q9VQB6

    Gene LinkOut

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