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    l(3)76BDm lethal (3) 76BDm [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40140, updated on 9-Dec-2024

    Summary

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    Official Symbol
    l(3)76BDmprovided by FlyBase
    Official Full Name
    lethal (3) 76BDmprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260655
    Locus tag
    Dmel_CG8793
    See related
    AllianceGenome:FB:FBgn0260655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8793; Dmel\CG8793; l(3)L3809; TRAPPC8
    Summary
    Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in Golgi apparatus. Part of TRAPPIII protein complex. Is expressed in adult head. Orthologous to human TRAPPC8 (trafficking protein particle complex subunit 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(3)76BDm in Genome Data Viewer
    Location:
    76B9-76B9; 3-45 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19613427..19618521, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19606527..19611621, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene lush Neighboring gene uncharacterized protein Neighboring gene Lon protease Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class F Neighboring gene anti-silencing factor 1 Neighboring gene male sterile (3) 76Cc

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Parcas is the predominant Rab11-GEF for rhodopsin transport in Drosophila photoreceptors. Otsuka Y, et al. J Cell Sci, 2019 Aug 7. PMID 31296556
    2. Cryo-EM structure of metazoan TRAPPIII, the multi-subunit complex that activates the GTPase Rab1. Galindo A, et al. EMBO J, 2021 Jun 15. PMID 34018214, Free PMC Article
    3. TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila. Robinett CC, et al. J Cell Sci, 2009 Dec 15. PMID 19934220, Free PMC Article
    4. Drosophila pipe protein activity in the ovary and the embryonic salivary gland does not require heparan sulfate glycosaminoglycans. Zhu X, et al. Development, 2005 Sep. PMID 16049108
    5. In vivo functional characterization of the SARS-Coronavirus 3a protein in Drosophila. Wong SL, et al. Biochem Biophys Res Commun, 2005 Nov 18. PMID 16212942, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of TRAPPIII protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPPIII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lethal (3) 76BDm
    Names
    CG8793-PA
    CG8793-PB
    l(3)76BDm-PA
    l(3)76BDm-PB
    lethal (3) L3809

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19613427..19618521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275129.1 → NP_001262058.1  lethal (3) 76BDm, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262058.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FNQ9, Q9VW22
      Conserved Domains (1) summary
      pfam12739
      Location:157 → 608
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit

    2. NM_140878.4 → NP_649135.2  lethal (3) 76BDm, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649135.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FNQ9, Q9VW22
      Related
      FBpp0074734
      Conserved Domains (1) summary
      pfam12739
      Location:157 → 608
      TRAPPC-Trs85; ER-Golgi trafficking TRAPP I complex 85 kDa subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TM6 Q95TM6
    Q9VW22 Q9VW22

    Gene LinkOut

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