U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Exo70 Exocyst 70 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38959, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Exo70provided by FlyBase
    Official Full Name
    Exocyst 70provided by FlyBase
    Primary source
    FLYBASE:FBgn0266667
    Locus tag
    Dmel_CG7127
    See related
    AllianceGenome:FB:FBgn0266667
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7127; Dmel\CG7127; exo70; Exo70p
    Summary
    Enables beta-catenin binding activity. Involved in synaptic assembly at neuromuscular junction. Located in terminal bouton. Is expressed in adult head and organism. Orthologous to human EXOC7 (exocyst complex component 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Exo70 in Genome Data Viewer
    Location:
    66C11-66C11; 3-24 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8411851..8415910)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8404951..8409010)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene monkey king protein Neighboring gene tRNA 2'-phosphotransferase Neighboring gene uncharacterized protein Neighboring gene Outer segment 1 Neighboring gene matrimony Neighboring gene uncharacterized protein Neighboring gene Cbl proto-oncogene Neighboring gene Upstream of N-ras

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3. Chen ZS, et al. Cell Death Dis, 2021 Feb 2. PMID 33542212, Free PMC Article
    2. Drosophila Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress. Koon AC, et al. J Neurosci, 2018 Sep 12. PMID 30209205, Free PMC Article
    3. A signalling cascade for Ral. Wu Y, et al. Small GTPases, 2022 Jan. PMID 33956571, Free PMC Article
    4. The exocyst complex is required for developmental and regenerative neurite growth in vivo. Swope RD, et al. Dev Biol, 2022 Dec. PMID 36162553, Free PMC Article
    5. PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes. Gass MM, et al. Cell Mol Life Sci, 2022 Apr 18. PMID 35437696, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3.
      Title: A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3.
    2. Exo70 is expressed in both glutamatergic and octopaminergic neurons, and presynaptic Exo70 regulates synaptic outgrowth. exo70 mutants have impaired integral membrane transport to the cell surface at synaptic terminals and block several kinds of induced synaptic growth. Elevated temperature causes severe arborization defects and lethality in exo70 mutants, underpinning the importance of Exo70 in development and adaptation
      Title: Drosophila Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle docking NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle targeting NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exocyst ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of exocyst NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    exocyst 70
    Names
    CG7127-PA
    Exo70 ortholog
    Exo70-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8411851..8415910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139965.3 → NP_648222.3  exocyst 70 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648222.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T0E9, Q9VSJ8
      UniProtKB/TrEMBL
      D5AEM7, H1UUN4
      Related
      FBpp0076339
      Conserved Domains (1) summary
      pfam03081
      Location:315 → 686
      Exo70; Exo70 exocyst complex subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSJ8.2 Q9VSJ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous