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    Argk2 Arginine kinase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39040, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Argk2provided by FlyBase
    Official Full Name
    Arginine kinase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035957
    Locus tag
    Dmel_CG5144
    See related
    AllianceGenome:FB:FBgn0035957
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AK-2; AK2; CG5144; Dmel\CG5144
    Summary
    Predicted to enable creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Predicted to be located in cytosol and mitochondrion. Predicted to be active in extracellular space. Is expressed in adult head and spermatozoon. Orthologous to several human genes including CKB (creatine kinase B); CKM (creatine kinase, M-type); and CKMT1A (creatine kinase, mitochondrial 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Argk2 in Genome Data Viewer
    Location:
    66F3-66F3; 3-28 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9047439..9048724)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9040539..9041824)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46451 Neighboring gene Dorsocross1 Neighboring gene Arginine kinase 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of the arginine kinase gene family. Uda K, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2006 Jun. PMID 20483252
    2. graal: a Drosophila gene coding for several mosaic serine proteases. Munier AI, et al. Insect Biochem Mol Biol, 2004 Oct. PMID 15475297
    3. Genetic variation in the shape of cold-survival curves in a single fly population suggests potential for selection from climate variability. Teets NM, et al. J Evol Biol, 2018 Apr. PMID 29345010
    4. The T-box-encoding Dorsocross genes function in amnioserosa development and the patterning of the dorsolateral germ band downstream of Dpp. Reim I, et al. Development, 2003 Jul. PMID 12783790
    5. Steroid Signaling Establishes a Female Metabolic State and Regulates SREBP to Control Oocyte Lipid Accumulation. Sieber MH, et al. Curr Biol, 2015 Apr 20. PMID 25802149, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables creatine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables creatine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphocreatine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    arginine kinase 2
    Names
    Argk2-PA
    CG5144-PA
    NP_648284.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9047439..9048724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140027.2 → NP_648284.1  arginine kinase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648284.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VST4, T1W135
      Related
      FBpp0076250
      Conserved Domains (1) summary
      cd07932
      Location:40 → 382
      arginine_kinase_like; Phosphagen (guanidino) kinases such as arginine kinase and similar enzymes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T8X7 Q8T8X7
    Q9VST4 Q9VST4

    Gene LinkOut

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